Statin equivalent-dose calculator
Statin dose equivalence
— in the «Доступні ліки» state reimbursement register
Modeled equivalent dose
Range 10–80 mg/day: Most patients fall within this range; an individual may differ.
Evidence: 3 of 5 stars: Reasonable method with moderate or indirect supporting evidence.
Why this estimate & cautions
Population-average equivalence on a surrogate endpoint (LDL-C reduction), not cardiovascular outcomes; an individual patient may fall outside the displayed band. Equipotent dose, not interchangeable product.
Statin dose conversion chart
Read each row across as roughly the same LDL-C lowering, modeled from the atorvastatin dose in the first column by a sourced log-linear dose-response. “‡” marks a dose capped at that statin's licensed maximum — it does not fully reach this LDL-C lowering, so it under-treats. Individual LDL-C response varies by roughly ±15 percentage points (VOYAGER), and switching between statins can under-dose the target — see Methods. Educational estimate, not a prescription.
| Atorvastatin (reference dose) | Atorvastatin intensity (ACC/AHA) | Atorvastatin | Rosuvastatin | Simvastatin | Pravastatin | Lovastatin | Fluvastatin | Pitavastatin |
|---|---|---|---|---|---|---|---|---|
| 10 mg | Moderate | 10 mg | 5 mg | 40 mg | 80 mg‡ | 40 mg | 80 mg‡ | 2 mg |
| 20 mg | Moderate | 20 mg | 10 mg | 80 mg‡ | 80 mg‡ | 63.5 mg | 80 mg‡ | 4 mg |
| 40 mg | High | 40 mg | 22.4 mg | 80 mg‡ | 80 mg‡ | 80 mg‡ | 80 mg‡ | 4 mg‡ |
| 80 mg | High | 80 mg | 40 mg‡ | 80 mg‡ | 80 mg‡ | 80 mg‡ | 80 mg‡ | 4 mg‡ |
Statin equivalent doses are doses of different statins modeled to lower LDL-C by the same percentage (e.g., atorvastatin 20 mg ≈ rosuvastatin 10 mg).
Statin doses and their intensity
Statins lower LDL-C, and clinical guidelines classify their doses by intensity — how much a dose lowers LDL-C from baseline, not by the number of milligrams. A moderate-intensity dose lowers LDL-C by roughly 30–49%, a high-intensity dose by 50% or more. For atorvastatin, 10–20 mg is moderate intensity and 40–80 mg is high.
Equal intensity only means the same expected LDL-C reduction. Individual response varies by about ±15 percentage points between patients, and the drugs differ in dose ceilings, metabolism, and propensity for muscle symptoms — so an equal dose in this table does not make two statins interchangeable. It is an educational estimate; the reference point is the LDL-C level actually reached, not the drug's name.
Evidence
References15
Oni-Orisan A, et al. (2018) (opens in a new tab) Characterization of Statin LDL-C Dose-response Utilizing Electronic Health Records in a Large Population-based Cohort. Circ Genom Precis Med.
Law MR, Wald NJ, Rudnicka AR (2003) (opens in a new tab) Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ.
Karlson BW, Wiklund O, Palmer MK, Nicholls SJ, Lundman P, Barter PJ (2016) (opens in a new tab) Variability of low-density lipoprotein cholesterol response with different doses of atorvastatin, rosuvastatin, and simvastatin: results from VOYAGER. Eur Heart J Cardiovasc Pharmacother.
Pfizer (FDA prescribing information) (2024) (opens in a new tab) LIPITOR (atorvastatin calcium) tablets — Dosage and Administration. DailyMed / FDA label.
AstraZeneca (FDA prescribing information) (2023) (opens in a new tab) CRESTOR (rosuvastatin) tablets — Dosage and Administration. DailyMed / FDA label.
Merck (FDA prescribing information) (2023) (opens in a new tab) ZOCOR (simvastatin) tablets — Dosage and Administration. DailyMed / FDA label.
Bristol-Myers Squibb (FDA prescribing information) (2023) (opens in a new tab) PRAVASTATIN SODIUM tablets — Dosage and Administration. DailyMed / FDA label.
Merck / generic (FDA prescribing information) (2023) (opens in a new tab) LOVASTATIN tablets — Dosage and Administration. DailyMed / FDA label.
Novartis / Sandoz (FDA prescribing information) (2023) (opens in a new tab) LESCOL XL (fluvastatin sodium) extended-release tablets — Dosage and Administration. DailyMed / FDA label.
Kowa (FDA prescribing information) (2024) (opens in a new tab) LIVALO (pitavastatin) tablets — Dosage and Administration. DailyMed / FDA label.
Bristol-Myers Squibb (FDA prescribing information) (2023) (opens in a new tab) PRAVASTATIN SODIUM tablets — Dosage and Administration. DailyMed / FDA label.
Novartis / Sandoz (FDA prescribing information) (2023) (opens in a new tab) LESCOL (fluvastatin sodium) capsules — Description and Dosage. DailyMed / FDA label.
Vo NX, Pham HL, Bui TT, Bui TT (2024) (opens in a new tab) Systematic Review on Efficacy, Effectiveness, and Safety of Pitavastatin in Dyslipidemia in Asia. Healthcare.
Karlson BW, Palmer MK, Nicholls SJ, Lundman P, Barter PJ (2016) (opens in a new tab) Doses of rosuvastatin, atorvastatin and simvastatin that induce equal reductions in LDL-C and non-HDL-C: results from the VOYAGER meta-analysis. Eur J Prev Cardiol.
Grundy SM, Stone NJ, Bailey AL, et al. (2019) (opens in a new tab) 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Circulation.
Method review — pending
Statin dose equivalents and «Affordable Medicines» reimbursement
Data current as of July 2026.