Single dose

Single-dose concentration over time

Concentration (mg/L)

048121620081624324048accumulationsteady stateTime (h)Concentration (mg/L)
Modeled estimate: peak 11.33 mg/L at 42.4 h, modeled exposure (AUC) 405.8 mg·h/L. Vertical marker: the modeled steady state is reached at about 32 h; the hatched zone before it is the accumulation phase.
Drug PK profile

Saturable absorption (Emax/D50)

Maximum bioavailability Emax
0.9
D₅₀ (half-saturation dose) (mg)
1800
Volume of distribution V (L)
60
Absorption rate ka (/h)
0.6
Elimination rate ke (/h)
0.115

Bioavailability vs dose

0.000.250.500.751.0001953905857809751170F = 0.60Dose (mg)F

Bioavailability F falls as the dose rises: absorption is saturable, so exposure does not scale with dose.

Modeled PK metrics

Peak (Cmax)
11.33 mg/L
Time to peak
42.4 h
Exposure (AUC)
405.8 mg·h/L
Time to steady state
≈ 32 h
Educational PK model: not clinical guidance. Confirm any dose change with a prescriber or pharmacist.