Single-dose concentration over time
Model the concentration-time profile for a single dosing regimen.
Published bioavailability drops from ~60% at 900 mg to ~33% at 3600 mg.
Bioavailability F falls as the dose rises — absorption is saturable, so exposure does not scale with dose.
Dosing-frequency comparison
For this drug, per-dose bioavailability depends on the per-dose amount. Splitting a fixed total daily dose across more administrations changes the modeled exposure. The schedules below split the same total daily dose four ways — these are modeled estimates from the parameters you entered, not dosing advice.
| Schedule | Per dose (mg) | F (modeled)How much of each dose reaches the bloodstream. | Daily AUC (mg·h/L)Total daily drug exposure. | Cmax (mg/L)The highest concentration reached. |
|---|---|---|---|---|
| QD (once daily) | 2700 | 0.36 | 140.87 | 13.582 |
| BID (twice daily) | 1350 | 0.51 | 201.24 | 12.435 |
| TID (three times daily) | 900 | 0.60 | 234.78 | 12.316 |
| QID (four times daily) | 675 | 0.65 | 256.12 | 12.404 |
This is a model output, not advice. For this total daily dose the model predicts that splitting it into more frequent doses changes the modeled exposure: daily AUC differs by about 82% between the once-daily and four-times-daily schedules.
These are modeled estimates from the parameters you entered, not dosing advice. Confirm any dose change with a prescriber or pharmacist.
Modeled estimates from the values you entered. Not a dose recommendation.