Dose-equivalence by class

Antipsychotic equivalent-dose calculator

Antipsychotic dose equivalence (olanzapine-equivalent)

Currently taking
Switching to

— in the «Доступні ліки» state reimbursement register

Olanzapine-equivalent modeled estimate

Risperidone
about3.8mg/day

Evidence: 3 of 5 stars: Reasonable method with moderate or indirect supporting evidence.

10 mg
Olanzapine
current
10 mg
Olanzapine
= 1 anchor
3.8 mg
Risperidone
equivalent
Olanzapine 10 mg/day maps to about Risperidone 3.8 mg/day. That's 10 mg/day of olanzapine on the equivalent scale. A population-average switching guide, not equipotency.
No gold standardPer Leucht 2015, a gold standard method for antipsychotic dose equivalence does not exist. Treat any single equivalent as approximate, and base switching decisions on a review of methods plus the clinical picture.
Why this estimate & cautions

Approximate population-average dose equivalence on the olanzapine-equivalent (Classical Mean Dose) scale, NOT bioequivalence or receptor-occupancy equivalence. Titrate against clinical response and tolerability.

Equivalence chart

Each drug expressed as the dose equivalent to Olanzapine 10 mg/day, by the published Classical Mean Dose method. No gold standard; population estimate, not a prescription.

DrugEquivalent dose
Olanzapine10 mg
Risperidone3.8 mg
Haloperidol7.4 mg
Chlorpromazine388.8 mg
Quetiapine322.7 mg
Aripiprazole14.1 mg
Ziprasidone79.2 mg
Amisulpride383.3 mg
Clozapine306.2 mg
Sertindole10.8 mg
Asenapine8.9 mg
Zotepine132.4 mg

Antipsychotic equivalent doses express each drug (e.g., olanzapine and risperidone) as an olanzapine-equivalent using the published Classical Mean Dose method; there is no gold-standard conversion, so this is an educational population estimate, not a prescription.

Evidence

References1

Leucht S, Samara M, Heres S, Patel MX, Furukawa T, Cipriani A, Geddes J, Davis JM (2015) (opens in a new tab) Dose Equivalents for Second-Generation Antipsychotic Drugs: The Classical Mean Dose Method. Schizophr Bull.

Method review — pending

Data current as of July 2026.

Educational PK model: not clinical guidance. Confirm any dose change with a prescriber or pharmacist.