Antidepressant equivalent-dose calculator
Antidepressant switch equivalence
— in the «Доступні ліки» state reimbursement register
Modeled equivalent dose
about49.3mg/day
Evidence: 3 of 5 stars: Reasonable method with moderate or indirect supporting evidence.
Why this estimate & cautions
Approximate acute-phase switching guide, not bioequivalence: based on population-average prescribed doses, not pharmacokinetics or receptor occupancy. Not for tapering or withdrawal.
Equivalence chart
Each drug expressed as the dose equivalent to Fluoxetine 20 mg/day, from peer-reviewed averages for acute depression. Population estimate, not a tapering guide. Educational, not a prescription.
| Drug | Equivalent dose |
|---|---|
| Fluoxetine | 20 mg |
| Citalopram | 20 mg |
| Sertraline | 49.3 mg |
| Escitalopram | 9 mg |
| Paroxetine | 17 mg |
| Fluvoxamine | 71.7 mg |
| Venlafaxine | 74.7 mg |
| Mirtazapine | 25.5 mg |
| Amitriptyline | 61.2 mg |
| Clomipramine | 58.1 mg |
| Nortriptyline | 50.5 mg |
Antidepressant equivalent doses express each drug (e.g., citalopram, sertraline and fluoxetine) as a fluoxetine-equivalent daily dose from peer-reviewed averages for acute depression; it is an educational population estimate, not a tapering or withdrawal guide and not a prescription.
Evidence
References4
Hayasaka Y, Purgato M, Magni LR, Ogawa Y, Takeshima N, Cipriani A, Barbui C, Leucht S, Furukawa TA (2015) (opens in a new tab) Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials. J Affect Disord.
Furukawa TA, Cipriani A, Cowen PJ, Leucht S, Egger M, Salanti G (2019) (opens in a new tab) Optimal dose of SSRIs, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis. Lancet Psychiatry.
McClelland J, Mathys M (2016) (opens in a new tab) Evaluation of QTc prolongation and dosage effect with citalopram. Ment Health Clin.
Hieronymus F, Nilsson S, Eriksson E (2016) (opens in a new tab) A mega-analysis of fixed-dose trials reveals dose-dependency and a low efficacy of citalopram 10 mg, paroxetine 10 mg and sertraline 50 mg as a class for the treatment of depression. Transl Psychiatry.
Method review — pending
Data current as of July 2026.