Dose-equivalence by class

Antidepressant equivalent-dose calculator

Equivalent doses

Each drug expressed as the dose equivalent to Citalopram 20 mg/day, from peer-reviewed averages for acute depression.

  • 20mg/day
  • 49.3mg/day
  • 9mg/day
  • 17mg/day
  • 71.7mg/day
  • 74.7mg/day
  • 25.5mg/day
  • 61.2mg/day
  • 58.1mg/day
  • 50.5mg/day

Sources (4)

Original

Hayasaka Y, Purgato M, Magni LR, Ogawa Y, Takeshima N, Cipriani A, Barbui C, Leucht S, Furukawa TA (2015) (opens in a new tab) Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials. J Affect Disord.

Original

Furukawa TA, Cipriani A, Cowen PJ, Leucht S, Egger M, Salanti G (2019) (opens in a new tab) Optimal dose of SSRIs, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis. Lancet Psychiatry.

Supporting

McClelland J, Mathys M (2016) (opens in a new tab) Evaluation of QTc prolongation and dosage effect with citalopram. Ment Health Clin.

Supporting

Hieronymus F, Nilsson S, Eriksson E (2016) (opens in a new tab) A mega-analysis of fixed-dose trials reveals dose-dependency and a low efficacy of citalopram 10 mg, paroxetine 10 mg and sertraline 50 mg as a class for the treatment of depression. Transl Psychiatry.

Method reviewpending

Data current as of July 2026.

Educational PK model: not clinical guidance. Confirm any dose change with a prescriber or pharmacist.