Dose-equivalence by class
PPI equivalent-dose calculator
Equivalence chart
Each PPI expressed as the dose equivalent to Omeprazole 20 mg by acid-suppression potency (effect on intragastric pH), from a peer-reviewed relative-potency table. Equal acid suppression does not prove equal clinical benefit. Educational, not a prescription.
| Drug | Equivalent dose |
|---|---|
| Omeprazole | 20 mg |
| Esomeprazole | 12.5 mg |
| Rabeprazole | 11 mg |
| Lansoprazole | 22.2 mg |
| Pantoprazole | 87 mg |
Proton-pump inhibitor equivalent doses express each PPI (e.g., omeprazole, esomeprazole and pantoprazole) on an omeprazole-equivalent scale from a peer-reviewed relative-potency table for acid suppression (effect on intragastric pH); it is an educational estimate of equal acid suppression, not proof of equal clinical benefit and not a prescription.
Data current as of June 2026.
Educational PK model: not clinical guidance. Confirm any dose change with a prescriber or pharmacist.