Dose-equivalence by class

PPI equivalent-dose calculator

Equivalent doses

Each PPI expressed as the dose equivalent to Omeprazole 20 mg by acid-suppression potency (effect on intragastric pH), from a peer-reviewed relative-potency table. Equal acid suppression does not prove equal clinical benefit.

  • ≈12.5mg/day
  • ≈11mg/day
  • ≈22.2mg/day
  • ≈87mg/day

Sources (2)

Graham DY, Tansel A (2018) (opens in a new tab) Interchangeable Use of Proton Pump Inhibitors Based on Relative Potency. Clin Gastroenterol Hepatol.

Kirchheiner J, Glatt S, Fuhr U, Klotz U, Meineke I, Seufferlein T, Brockmöller J (2009) (opens in a new tab) Relative potency of proton-pump inhibitors—comparison of effects on intragastric pH. Eur J Clin Pharmacol.

Method review — pending

Data current as of July 2026.

Educational PK model: not clinical guidance. Confirm any dose change with a prescriber or pharmacist.