Dose-equivalence by class

ACE inhibitor equivalent-dose calculator

ACE-inhibitor dose equivalence (low confidence)

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Low-confidence estimateThis is a WHO Defined-Daily-Dose-anchored ratio, NOT clinical equipotency. The DDD is a drug-utilization unit and does not necessarily reflect the prescribed dose. Sometimes it is a dose rarely if ever prescribed. Treat as a low-confidence fallback and titrate against measured blood pressure.

WHO DDD-anchored equivalent (not equipotency)

Enalapril
about20mg/day

Evidence: 2 of 5 stars: Weak or extrapolated basis: interpret with particular caution.

Ramipril 5 mg/day maps to about Enalapril 20 mg/day by the WHO DDD ratio. A low-confidence estimate, not equipotency.
Why this estimate & cautions
DDD is not equipotencySee the low-confidence note at the top of this result.
Duration of actionThe DDD ratio ignores duration of action: ramipril, perindopril, and lisinopril are dosed once daily, whereas enalapril and captopril often need divided dosing. A single mg-ratio cannot be read as a regimen equivalence. Adjust the dosing interval accordingly.

Equivalence chart

Doses by WHO defined-daily-dose ratio relative to Ramipril 5 mg — a low-confidence approximation, not true equipotency. Educational only, not a prescription.

DrugEquivalent dose
Captopril100 mg
Enalapril20 mg
Lisinopril20 mg
Perindopril8 mg
Ramipril5 mg

ACE inhibitor equivalent doses here compare ramipril, enalapril and lisinopril by their WHO defined-daily-dose ratio — a low-confidence approximation, because no validated closed-form conversion exists and defined daily doses measure drug utilization, not equipotency; educational only, not a prescription.

Evidence

References3

WHO Collaborating Centre for Drug Statistics Methodology (2024) (opens in a new tab) ATC/DDD Index, group C09AA (ACE inhibitors, plain). WHO ATC/DDD Index.

WHO Collaborating Centre for Drug Statistics Methodology (2024) (opens in a new tab) DDD: Definition and general considerations. WHO ATC/DDD Index.

Fischer K, Diec S (2021) (opens in a new tab) Once- Versus Twice-Daily ACE Inhibitors for BP Control in Adults With Hypertension. Cureus.

Method review — pending

Data current as of July 2026.

Educational PK model: not clinical guidance. Confirm any dose change with a prescriber or pharmacist.