:root{interpolate-size:allow-keywords;--color-page-bg: #f8fafc;--color-card-bg: #ffffff;--color-text: #0f172a;--color-text-muted: #475569;--color-border: #e2e8f0;--color-banner-bg: #fef9c3;--color-banner-text: #713f12;--color-banner-border: #facc15;--color-dose-a: #0d9488;--color-dose-a-text: #0f766e;--color-dose-b: #4f46e5;--color-dose-b-text: #4338ca;--color-focus-ring: #0f766e;--color-error: #b91c1c;--color-tier-a: #166534;--color-tier-b: #854d0e;--color-tier-c: #9f1239;--color-refusal-bg: #fef2f2;--color-refusal-text: #7f1d1d;--color-refusal-border: #fca5a5;--radius: 8px;--gap: 1rem}html{font-size:16px;scroll-padding-top:8.5rem}html,body,#root{margin:0;padding:0;background:var(--color-page-bg);color:var(--color-text);font-family:-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,sans-serif;line-height:1.45}body{font-size:1rem}.app{min-height:100vh;display:flex;flex-direction:column}.disclaimer-footer{padding:.75rem 1rem 1rem;font-size:.75rem;color:var(--color-text-muted);opacity:.6;text-align:center}.header{display:flex;align-items:center;justify-content:space-between;padding:.75rem 1rem;background:var(--color-card-bg);border-bottom:1px solid var(--color-border);gap:.5rem 1rem;flex-wrap:wrap;position:sticky;top:0;z-index:50;box-shadow:0 1px #0f172a0a,0 2px 6px #0f172a0a}.header h1{font-size:1.5rem;margin:0;font-weight:600}.header-intro{flex-basis:100%;margin:0;font-size:.875rem;color:var(--color-text-muted)}.skip-link{position:absolute;left:.5rem;top:-3rem;z-index:100;padding:.5rem .85rem;background:var(--color-card-bg);color:var(--color-dose-a-text);border:2px solid var(--color-focus-ring);border-radius:var(--radius);font-size:.9375rem;text-decoration:none;transition:top .15s ease}@media (prefers-reduced-motion: reduce){.skip-link{transition:none}}.mode-toggle,.language-toggle{display:inline-flex;border:1px solid var(--color-border);border-radius:var(--radius);overflow:hidden}.mode-toggle button,.language-toggle button{background:transparent;border:none;padding:.4rem .8rem;cursor:pointer;font-size:.9375rem;color:var(--color-text-muted)}.mode-toggle button.active,.language-toggle button.active{background:var(--color-text);color:#fff}.header-controls{display:inline-flex;align-items:center;gap:.5rem;flex-wrap:wrap}.language-toggle button{font-weight:600;letter-spacing:.04em;padding:.4rem .6rem}.dashboard{display:flex;flex-direction:column;gap:var(--gap);padding:var(--gap);flex:1}.card{background:var(--color-card-bg);border:1px solid var(--color-border);border-radius:var(--radius);padding:1rem}.card h2{font-size:1.25rem;margin:0 0 .5rem;font-weight:600}.card h3{font-size:1.0625rem;margin:0 0 .5rem;font-weight:600;color:var(--color-text-muted);text-transform:uppercase;letter-spacing:.05em}h2{font-size:1.25rem}h3{font-size:1.0625rem}.preset-picker{display:flex;align-items:center;gap:.5rem;flex-wrap:wrap}.preset-picker select{padding:.4rem .5rem;border-radius:var(--radius);border:1px solid var(--color-border);background:#fff;font-size:1rem}.parameter-panels{display:grid;grid-template-columns:1fr 1fr;gap:var(--gap)}.dose-panel{background:var(--color-card-bg);border:1px solid var(--color-border);border-radius:var(--radius);padding:.75rem;border-top:3px solid}.dose-panel .label-row{display:flex;align-items:center;justify-content:space-between;margin-bottom:.5rem}.dose-panel .label-row .dot{display:inline-block;width:.7rem;height:.7rem;border-radius:50%}.dose-panel h2{font-size:1.0625rem;margin:0;font-weight:600}.dose-panel h3{font-size:.9375rem;margin:0;font-weight:600;color:var(--color-text-muted);text-transform:uppercase;letter-spacing:.04em}.dose-panel label{display:flex;flex-direction:column;margin-bottom:.4rem;font-size:.9375rem;color:var(--color-text-muted)}.dose-panel input{margin-top:.15rem;padding:.3rem .4rem;font-size:.9375rem;border:1px solid var(--color-border);border-radius:4px}.dose-panel input[aria-invalid=true]{border-color:var(--color-error);background:#fef2f2}.fields-grid{display:grid;grid-template-columns:1fr 1fr;gap:.5rem}.callout{background:linear-gradient(135deg,#ecfeff,#fdf4ff);border:1px solid var(--color-border);border-radius:var(--radius);padding:.9rem 1rem;margin-bottom:.75rem;font-size:1rem}.callout .headline{font-size:1.125rem;font-weight:700;margin:0 0 .25rem}.callout .sub{margin:0;color:var(--color-text-muted);font-size:.9375rem}.metrics-table{width:100%;font-size:.9375rem;border-collapse:collapse}.metrics-table caption{caption-side:top;text-align:left;font-size:.9375rem;font-weight:600;color:var(--color-text-muted);padding-bottom:.4rem}.metrics-table th,.metrics-table td{text-align:right;padding:.3rem .5rem;border-bottom:1px solid var(--color-border)}.metrics-table th:first-child,.metrics-table td:first-child{text-align:left;color:var(--color-text-muted)}.metrics-table th.col-a{color:var(--color-dose-a-text)}.metrics-table th.col-b{color:var(--color-dose-b-text)}.small-multiples{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1fr);gap:var(--gap)}.chart-card{background:var(--color-card-bg);border:1px solid var(--color-border);border-radius:var(--radius);padding:.75rem}.tile-row{display:flex;gap:.75rem;margin-bottom:.75rem}.tile{flex:1;border-left:4px solid;padding:.5rem .75rem;background:#f8fafc;border-radius:6px}.tile .tile-label{font-size:.875rem;color:var(--color-text-muted);text-transform:uppercase;letter-spacing:.04em}.tile .tile-value{font-size:1.25rem;font-weight:600}.tile.dose-a{border-left-color:var(--color-dose-a)}.tile.dose-b{border-left-color:var(--color-dose-b)}.foot-note{font-size:.875rem;color:var(--color-text-muted);margin-top:.5rem}.btn{cursor:pointer;background:var(--color-card-bg);color:var(--color-text);border:1px solid var(--color-border);border-radius:var(--radius);padding:.4rem .7rem;font-size:.9375rem;font-weight:500}.btn:hover{background:#f1f5f9}.btn-primary{background:var(--color-text);color:#fff;border-color:var(--color-text)}.btn-primary:hover{background:#1e293b}.btn-add{color:var(--color-dose-a-text);border-color:var(--color-dose-a)}.btn-add:hover{background:#0d948814}.btn-danger{color:var(--color-error);border-color:#fecaca}.btn-danger:hover{background:#fef2f2}.cdd-backdrop{position:fixed;top:0;right:0;bottom:0;left:0;background:#0f172a80;display:flex;align-items:center;justify-content:center;padding:1rem;z-index:100}.cdd-modal{background:var(--color-card-bg);border-radius:var(--radius);width:100%;max-width:640px;max-height:90vh;overflow-y:auto;padding:1.25rem;box-shadow:0 20px 50px #0f172a40;display:flex;flex-direction:column;gap:.85rem}.cdd-header{display:flex;justify-content:space-between;align-items:center}.cdd-header h2{margin:0;font-size:1.05rem;font-weight:600}.cdd-close{background:transparent;border:none;font-size:1.6rem;line-height:1;cursor:pointer;color:var(--color-text-muted);padding:0 .25rem}.cdd-close:hover{color:var(--color-text)}.cdd-help{margin:0;font-size:.78rem;color:var(--color-text-muted);background:var(--color-banner-bg);border-left:3px solid var(--color-banner-border);padding:.45rem .6rem;border-radius:4px}.cdd-row{display:flex;gap:.6rem}.cdd-field{display:flex;flex-direction:column;font-size:.75rem;color:var(--color-text-muted);gap:.2rem}.cdd-field input,.cdd-field select{padding:.4rem .5rem;border:1px solid var(--color-border);border-radius:4px;font-size:.85rem;color:var(--color-text);background:#fff}.cdd-grow{flex:1}.cdd-fieldset{border:1px solid var(--color-border);border-radius:var(--radius);padding:.6rem .8rem .8rem;margin:0}.cdd-fieldset legend{font-size:.78rem;font-weight:600;color:var(--color-text-muted);text-transform:uppercase;letter-spacing:.04em;padding:0 .4rem}.cdd-grid{display:grid;grid-template-columns:repeat(2,1fr);gap:.6rem}.cdd-pair{display:grid;grid-template-columns:1fr 1fr;gap:.8rem}.cdd-pair-col h4{margin:0 0 .4rem;font-size:.8rem;font-weight:600;color:var(--color-text-muted)}.cdd-error{background:#fef2f2;border:1px solid #fecaca;color:#b91c1c;padding:.5rem .7rem;border-radius:4px;font-size:.8rem}.cdd-footer{display:flex;justify-content:flex-end;gap:.5rem}@media (max-width: 560px){.cdd-grid,.cdd-pair{grid-template-columns:1fr}}.drug-profile-disclosure{margin-top:.5rem}.drug-profile-disclosure>summary{list-style:none;cursor:pointer;display:inline-flex;align-items:center;gap:.35rem;background:var(--color-card-bg);color:var(--color-text);border:1px solid var(--color-border);border-radius:var(--radius);padding:.3rem .6rem;font-size:.875rem;font-weight:500;-webkit-user-select:none;user-select:none}.drug-profile-disclosure>summary::-webkit-details-marker{display:none}.drug-profile-disclosure>summary:before{content:"";display:inline-block;width:0;height:0;border-left:5px solid currentColor;border-top:4px solid transparent;border-bottom:4px solid transparent;transition:transform .12s ease}.drug-profile-disclosure[open]>summary:before{transform:rotate(90deg)}.drug-profile-disclosure>summary:hover{background:#f1f5f9}.drug-profile-disclosure>h3{margin-top:.6rem}.info-tooltip-wrapper{position:relative;display:inline-flex;align-items:center;gap:.3rem;margin-left:.3rem;margin-block:-5px}.info-tooltip-trigger{position:relative;display:inline-flex;align-items:center;justify-content:center;min-width:24px;min-height:24px;padding:0;border:none;background:transparent;color:var(--color-text-muted);font-size:10px;line-height:1;font-weight:700;cursor:help}.info-tooltip-trigger:before{content:"";position:absolute;top:50%;left:50%;width:14px;height:14px;transform:translate(-50%,-50%);border:1px solid currentColor;border-radius:50%}.info-tooltip-trigger:hover,.info-tooltip-trigger:focus-visible{color:var(--color-focus-ring)}.info-tooltip-bubble{position:absolute;bottom:calc(100% + 6px);left:0;max-width:280px;width:max-content;background:#0f172a;color:#fff;padding:.45rem .6rem;border-radius:4px;font-size:.8rem;font-weight:400;line-height:1.35;box-shadow:0 4px 12px #0f172a40;z-index:30;pointer-events:none;white-space:normal;text-transform:none;letter-spacing:0}.info-tooltip-bubble[hidden]{display:none}.auto-match-button-row{margin-bottom:.5rem}.auto-match-button{font-size:.875rem;padding:.3rem .55rem;color:var(--color-dose-b-text);border-color:var(--color-dose-b);background:#c026d30a}.auto-match-button:hover:not(:disabled){background:#c026d31a}.auto-match-button:disabled{opacity:.5;cursor:not-allowed}.auto-match-checks{display:flex;flex-wrap:wrap;gap:.75rem}.auto-match-check{display:inline-flex;align-items:center;gap:.35rem;font-size:.85rem;color:var(--color-text)}.auto-match-radios{display:flex;flex-direction:column;gap:.5rem}.auto-match-radio{display:flex;gap:.5rem;align-items:flex-start;font-size:.85rem}.auto-match-radio input{margin-top:.2rem}.auto-match-radio-label{display:block;font-weight:500;color:var(--color-text)}.auto-match-radio-hint{display:block;font-size:.75rem;color:var(--color-text-muted)}.auto-match-hint{margin:.5rem 0 0;font-size:.75rem;color:#b45309}.auto-match-live-hint{margin:.5rem 0 0;font-size:.75rem;color:var(--color-text-muted)}.auto-match-actions{display:flex;justify-content:flex-end;gap:.5rem}.auto-match-result{border-top:1px solid var(--color-border);padding-top:.75rem;display:flex;flex-direction:column;gap:.6rem}@keyframes auto-match-result-fade-in{0%{opacity:.6}to{opacity:1}}.auto-match-result-fade{animation-name:auto-match-result-fade-in;animation-timing-function:ease-out;animation-fill-mode:both}@keyframes auto-match-result-tint{0%{background-color:#5eead42e}to{background-color:transparent}}.auto-match-result-tint{animation:auto-match-result-tint .32s ease-out 1}@media (prefers-reduced-motion: reduce){.auto-match-result-fade{animation:none}}.auto-match-result h3{margin:0;font-size:.85rem;font-weight:600;color:var(--color-text-muted);text-transform:uppercase;letter-spacing:.04em}.auto-match-quality{display:inline-block;align-self:flex-start;padding:.2rem .55rem;border-radius:999px;font-size:.78rem;font-weight:600;border:1px solid transparent}.auto-match-quality-excellent{background:#dcfce7;color:#166534;border-color:#86efac}.auto-match-quality-good{background:#ecfccb;color:#3f6212;border-color:#bef264}.auto-match-quality-moderate{background:#fef3c7;color:#92400e;border-color:#fcd34d}.auto-match-quality-poor{background:#fee2e2;color:#991b1b;border-color:#fca5a5}.auto-match-rows{list-style:none;margin:0;padding:0;display:flex;flex-direction:column;gap:.25rem}.auto-match-row{display:flex;justify-content:space-between;padding:.3rem .5rem;border-radius:4px;background:#f8fafc;font-size:.85rem}.auto-match-row-label{color:var(--color-text-muted)}.auto-match-row.is-free .auto-match-row-value{font-weight:700;color:var(--color-dose-b-text)}.auto-match-row.is-locked{opacity:.7}.auto-match-row.is-locked .auto-match-row-value{color:var(--color-text-muted)}.auto-match-locked-suffix{font-size:.7rem;font-weight:500;margin-left:.25rem}.auto-match-distance{margin:0;font-size:.8rem;color:var(--color-text-muted);font-family:ui-monospace,SFMono-Regular,Menlo,monospace}.auto-match-warnings{background:#fffbeb;border:1px solid #fde68a;border-radius:4px;padding:.5rem .7rem;font-size:.78rem}.auto-match-warnings strong{display:block;margin-bottom:.25rem;color:#92400e}.auto-match-warnings ul{margin:0;padding-left:1.1rem;color:#78350f}@media (max-width: 720px){.small-multiples{grid-template-columns:1fr}}@media (max-width: 560px){.parameter-panels{grid-template-columns:1fr}.header h1{font-size:1rem}.disclaimer-footer{font-size:.7rem}.tile-row{flex-direction:column}.header-intro{display:none}.header{padding:.5rem .85rem}}@media (max-width: 360px){body{font-size:14px}.dashboard{padding:.5rem;gap:.5rem}.card{padding:.6rem}}.regimen-summary{display:flex;flex-direction:column;gap:.4rem;background:var(--color-card-bg);border:1px solid var(--color-border);border-radius:var(--radius);padding:.6rem .85rem}.regimen-summary dl{display:grid;grid-template-columns:max-content 1fr;gap:.25rem .6rem;margin:0;padding:.3rem 0 .3rem .6rem;border-left:4px solid;font-size:.9375rem}.regimen-summary dl.dose-a{border-left-color:var(--color-dose-a)}.regimen-summary dl.dose-b{border-left-color:var(--color-dose-b)}.regimen-summary dt{font-weight:600;color:var(--color-text)}.regimen-summary dl.dose-a dt{color:var(--color-dose-a-text)}.regimen-summary dl.dose-b dt{color:var(--color-dose-b-text)}.regimen-summary dd{margin:0;color:var(--color-text-muted)}.field-error{margin:.25rem 0 0;color:var(--color-error);font-size:.875rem;font-weight:500}.field-note{margin:.25rem 0 0;color:var(--color-text-muted);font-size:.8125rem;font-weight:400}.stale{opacity:.6;pointer-events:none;background-image:repeating-linear-gradient(135deg,rgba(148,163,184,.06),rgba(148,163,184,.06) 6px,transparent 6px,transparent 12px)}.stale-notice{margin:0 0 .5rem;padding:.45rem .7rem;background:#fffbeb;border:1px solid #fde68a;border-radius:4px;color:#92400e;font-size:.9375rem}figure.chart-figure{margin:0;display:contents}.chart-caption{margin:0 0 .4rem;font-size:.875rem;color:var(--color-text-muted);line-height:1.4}.field-hint{margin:0 0 .35rem;font-size:.875rem;color:var(--color-text-muted);line-height:1.4}.dialog-notice{margin:0;padding:.55rem .75rem;background:#fffbeb;border:1px solid #fde68a;border-left:4px solid #b45309;border-radius:4px;color:#92400e;font-size:.9375rem;line-height:1.4}.evidence-badge{display:inline-flex;align-items:center;gap:.25rem;font-size:.75rem;font-weight:600;line-height:1;padding:.2rem .5rem;border:1.5px solid currentColor}.evidence-badge-srlabel{font-weight:400}.evidence-badge-A{color:var(--color-tier-a);border-radius:999px}.evidence-badge-B{color:var(--color-tier-b);border-radius:4px}.evidence-badge-C{color:var(--color-tier-c);border-radius:0;border-style:dashed}.citation-disclosure{display:block}.citation-disclosure>summary{list-style:none;cursor:pointer;display:inline-flex;align-items:center;gap:.3rem;min-height:24px;padding:.25rem 0;font-size:.8rem;font-weight:600;color:var(--color-text-muted);-webkit-user-select:none;user-select:none}.citation-disclosure>summary::-webkit-details-marker{display:none}.citation-disclosure>summary:before{content:"";display:inline-block;width:0;height:0;border-left:5px solid currentColor;border-top:4px solid transparent;border-bottom:4px solid transparent;transition:transform .12s ease}.citation-disclosure[open]>summary:before{transform:rotate(90deg)}.citation-disclosure>summary:hover{color:var(--color-focus-ring)}.citation-panel{margin-top:.5rem;max-width:100%;background:var(--color-page-bg);color:var(--color-text);border:1px solid var(--color-border);border-radius:var(--radius);padding:.6rem .7rem;font-size:.8rem;font-weight:400}@supports (interpolate-size: allow-keywords){.citation-disclosure::details-content{block-size:0;overflow:clip;transition:block-size .3s ease,content-visibility .3s allow-discrete}.citation-disclosure[open]::details-content{block-size:auto}}.citation-lead{margin:0 0 .5rem;padding-bottom:.5rem;border-bottom:1px solid var(--color-border);font-weight:600;color:var(--color-text)}.citation-list{margin:0;padding:0;list-style:none;text-align:left}.citation-item+.citation-item{margin-top:.5rem;padding-top:.5rem;border-top:1px solid var(--color-border)}.citation-link{color:inherit;font-weight:600;text-decoration:underline}.citation-identifier{opacity:.85;font-size:.8em}.citation-quote-figure{margin:.35rem 0 0}.citation-quote-frame{font-size:.75em;opacity:.85;margin-bottom:.15rem}.citation-quote{margin:0;padding-left:.5rem;border-left:2px solid currentColor;font-style:italic}.citation-quote-pending{margin:.35rem 0 0;font-style:italic;opacity:.85}.refusal-banner{border:1px solid var(--color-refusal-border);background:var(--color-refusal-bg);color:var(--color-refusal-text);border-radius:var(--radius);padding:.75rem 1rem}.refusal-banner-heading{margin:0 0 .25rem;font-size:1rem}.refusal-banner-reason{margin:0}.refusal-banner-alternative{margin:.5rem 0 0}.fractional-panel{margin-top:var(--gap)}.fractional-input{display:flex;align-items:baseline;flex-wrap:wrap;gap:.5rem;margin:.75rem 0}.fractional-input label{font-size:.9375rem;font-weight:600;color:var(--color-text-muted)}.fractional-input-control{display:inline-flex;align-items:baseline;gap:.35rem}.fractional-input input{width:7rem;max-width:100%;padding:.35rem .5rem;font-size:.9375rem;font-family:var(--mono);border:1px solid var(--color-border);border-radius:6px;background:var(--color-card-bg);color:var(--color-text)}.fractional-input-unit{font-size:.875rem;font-family:var(--mono);color:var(--color-text-muted)}.fractional-table-scroll{max-width:100%;overflow-x:auto;-webkit-overflow-scrolling:touch}.fractional-table{margin-top:.25rem;min-width:30rem}.fractional-table th[scope=row]{text-align:left;font-weight:500;color:var(--color-text)}.fractional-table thead .info-tooltip-wrapper{margin-left:.25rem}.fractional-out-of-range{text-align:left;font-style:italic;color:var(--color-text-muted)}.fractional-delta{margin:.6rem 0 0;font-size:.9375rem;line-height:1.4}.fractional-safety-framing{margin:.6rem 0 0;font-size:1rem;line-height:1.45;color:var(--color-text)}.fractional-out-of-band{border:1px solid var(--color-border);background:var(--color-page-bg);border-radius:var(--radius);padding:.75rem 1rem;margin-top:.6rem}.fractional-out-of-band-heading{margin:0 0 .25rem;font-size:1rem;color:var(--color-text)}.fractional-out-of-band-body{margin:0;color:var(--color-text-muted)}.fractional-evidence{display:flex;align-items:center;flex-wrap:wrap;gap:.5rem;margin-top:.6rem}:focus-visible{outline:2px solid var(--color-focus-ring);outline-offset:2px;border-radius:4px}.btn:focus-visible,.mode-toggle button:focus-visible,.language-toggle button:focus-visible,.tile:focus-visible,.dose-panel input:focus-visible,.preset-picker select:focus-visible,.cdd-field input:focus-visible,.cdd-field select:focus-visible{outline:2px solid var(--color-focus-ring);outline-offset:2px}.mode-toggle button.active:focus-visible,.language-toggle button.active:focus-visible{outline-color:#5eead4}.equivalence-view{display:flex;flex-direction:column;flex:1}.equivalence-main{display:flex;flex-direction:column;gap:var(--gap);padding:var(--gap);flex:1;width:100%;max-width:1700px}.equivalence-title{margin:0;font-size:1.4rem}.equivalence-intro{margin:0;color:var(--color-text-muted);font-size:.95rem}.equivalence-subnav{display:inline-flex;align-self:flex-start;border:1px solid var(--color-border);border-radius:var(--radius);overflow:hidden}.equivalence-subnav button{background:transparent;border:none;padding:.4rem .8rem;cursor:pointer;font-size:.9375rem;color:var(--color-text-muted)}.equivalence-subnav button.active{background:var(--color-text);color:#fff}.equivalence-subnav button:focus-visible{outline:2px solid var(--color-focus-ring);outline-offset:-2px}.equivalence-panel{background:var(--color-card-bg);border:1px solid var(--color-border);border-radius:var(--radius);padding:var(--gap);display:grid;grid-template-columns:minmax(260px,340px) 1fr;gap:.75rem 1.5rem;align-items:start}.equivalence-panel-head{grid-column:1 / -1;display:flex;flex-direction:column;gap:.25rem}.equivalence-form-col{display:flex;flex-direction:column;gap:.75rem}.equivalence-output-col{min-width:0}.equivalence-panel-title{margin:0;font-size:1.1rem}.equivalence-panel-summary{margin:0;color:var(--color-text-muted);font-size:.9rem}.equivalence-form{display:flex;flex-direction:column;gap:.75rem}.equivalence-form label{display:flex;flex-direction:column;gap:.25rem;font-size:.9rem}.equivalence-form select,.equivalence-form input{padding:.5rem;border:1px solid var(--color-border);border-radius:var(--radius);font-size:1rem;background:var(--color-card-bg);color:var(--color-text)}.equivalence-form select:focus-visible,.equivalence-form input:focus-visible{outline:2px solid var(--color-focus-ring);outline-offset:1px}.equivalence-result{min-width:0}.result-grid{display:grid;grid-template-columns:minmax(300px,440px) 1fr;gap:var(--gap) 2.5rem;align-items:start}.result-primary,.result-secondary{min-width:0;display:flex;flex-direction:column;gap:.6rem}@media (max-width: 1120px){.result-grid{grid-template-columns:1fr}}.equivalence-result-heading{margin:0 0 .5rem;font-size:1rem}.equivalence-point{margin:0;font-size:1.5rem;font-weight:700}.equivalence-range,.equivalence-fluox{margin:.15rem 0;font-size:1rem}.equivalence-pct{margin:.15rem 0;color:var(--color-text-muted);font-size:.9rem}.equivalence-badge-row{margin:.4rem 0}.equivalence-note{margin:.5rem 0;padding:.5rem .65rem;border-left:3px solid var(--color-banner-border);background:var(--color-banner-bg);color:var(--color-banner-text);border-radius:4px;font-size:.88rem}.equivalence-caveat{margin-top:.75rem;font-size:.85rem;color:var(--color-text-muted)}.equivalence-caveat h5{margin:0 0 .25rem;font-size:.85rem;color:var(--color-text)}.equivalence-caveat p{margin:.25rem 0}.equivalence-safety-warning{margin:0 0 .75rem;padding:.65rem .8rem;border:2px solid var(--color-refusal-border);background:var(--color-refusal-bg);color:var(--color-refusal-text);border-radius:var(--radius);font-size:.9rem;line-height:1.4}.equivalence-safety-icon{font-size:1.1rem;line-height:1}.equivalence-point-prohibited{font-size:1.05rem;font-weight:500;color:var(--color-text-muted)}.equivalence-point-prohibited>s{text-decoration-thickness:2px}.equivalence-point-prohibited-note{display:block;margin-top:.15rem;font-size:.95rem;font-weight:700;color:var(--color-refusal-text)}.equivalence-range-gloss{margin:.1rem 0 .25rem;font-size:.85rem;color:var(--color-text-muted)}.equivalence-dose-hint{margin:.5rem 0 0;font-size:.9rem;color:var(--color-text-muted)}@media (max-width: 760px){.equivalence-panel{grid-template-columns:1fr}.equivalence-result{border-top:1px solid var(--color-border);padding-top:.75rem}}@media (max-width: 480px){.equivalence-main{padding:.5rem}.equivalence-point{font-size:1.3rem}}:root{--bg: #eef1f5;--surface: #ffffff;--surface-2: #f6f8fa;--ink: #16202e;--ink-2: #41505f;--muted: #6b7888;--muted-strong: #586271;--line: #e2e7ee;--line-2: #d3dae3;--brand: #0f766e;--brand-600: #0d9488;--brand-bg: #eafaf6;--indigo: #4f46e5;--tier-a: #166534;--tier-b: #92600c;--tier-c: #9f1239;--warn: #92600c;--warn-bg: #fdf6e7;--danger: #9f1239;--danger-bg: #fdeef1;--r-sm: 7px;--r: 11px;--r-lg: 16px;--shadow-card: 0 1px 2px rgba(22,32,46,.05), 0 6px 20px -10px rgba(22,32,46,.14);--shadow-pop: 0 12px 40px -12px rgba(22,32,46,.28);--font: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Helvetica, Arial, sans-serif;--mono: ui-monospace, SFMono-Regular, "SF Mono", Menlo, Consolas, monospace}.app-shell{max-width:1000px;margin:0 auto;padding:0 20px 64px}.appbar{position:sticky;top:0;z-index:40;display:flex;align-items:center;gap:16px;padding:16px 20px 14px;margin-bottom:4px;background:linear-gradient(var(--bg) 72%,rgba(238,241,245,0))}.brand{display:flex;align-items:center;gap:11px;margin-right:auto}.brand-mark{width:34px;height:34px;border-radius:9px;flex:none;background:var(--brand);position:relative;box-shadow:inset 0 0 0 1px #ffffff1f}.brand-mark:before,.brand-mark:after{content:"";position:absolute;background:#fff;border-radius:2px}.brand-mark:before{width:16px;height:3px;left:9px;top:15.5px}.brand-mark:after{width:3px;height:16px;left:15.5px;top:9px}.brand-text{display:flex;flex-direction:column;line-height:1.15}.brand-title{font-size:16px;font-weight:650;letter-spacing:-.01em;margin:0}.brand-sub{font-size:12px;color:var(--muted-strong)}.seg{display:inline-flex;background:var(--surface-2);border:1px solid var(--line);border-radius:999px;padding:3px;gap:2px}.seg-btn{border:none;background:transparent;cursor:pointer;padding:7px 15px;border-radius:999px;font-size:14px;font-weight:550;color:var(--ink-2);white-space:nowrap;transition:background .15s,color .15s}.seg-btn:hover{color:var(--ink)}.seg-btn.is-active{background:var(--surface);color:var(--brand);box-shadow:0 1px 2px #16202e1f}.seg-sm .seg-btn{padding:5px 12px;font-size:13px}.lang-toggle{display:inline-flex;border:1px solid var(--line);border-radius:999px;overflow:hidden;background:var(--surface)}.lang-toggle button{border:none;background:transparent;cursor:pointer;padding:7px 12px;font-size:12.5px;font-weight:650;letter-spacing:.04em;color:var(--muted)}.lang-toggle button.is-active{background:var(--ink);color:#fff}.mode-nav{display:flex;justify-content:center;margin:2px 0 22px}@media (max-width: 560px){.mode-nav{justify-content:flex-start;overflow-x:auto;-webkit-overflow-scrolling:touch;scrollbar-width:thin;padding-bottom:4px;-webkit-mask-image:linear-gradient(to right,#000 calc(100% - 20px),transparent 100%);mask-image:linear-gradient(to right,#000 calc(100% - 20px),transparent 100%)}.mode-nav .seg{flex:none}.mode-nav .seg-btn{padding:7px 12px;font-size:13px}}.mode-wrap{opacity:1}.mode-head{margin-bottom:18px}.mode-title{font-size:25px;font-weight:680;letter-spacing:-.02em;margin:0 0 5px}.mode-intro{margin:0;color:var(--ink-2);font-size:15.5px;max-width:64ch;text-wrap:pretty}.class-switch{margin-bottom:16px}.field{display:inline-flex;flex-direction:column;gap:5px}.field-label{font-size:12.5px;font-weight:600;color:var(--muted);letter-spacing:.01em}.select-wrap select{-moz-appearance:none;appearance:none;-webkit-appearance:none;border:1px solid var(--line-2);background:var(--surface);color:var(--ink);border-radius:var(--r-sm);padding:9px 32px 9px 12px;font-size:15px;font-weight:550;font-family:inherit;cursor:pointer;min-width:150px}.select-caret{position:absolute;right:12px;pointer-events:none;color:var(--muted);font-size:11px}.num-wrap input{border:1px solid var(--line-2);background:var(--surface);color:var(--ink);border-radius:var(--r-sm);padding:9px 12px;font-size:15px;font-weight:600;font-family:inherit;width:100%;min-width:92px;-moz-appearance:textfield;-webkit-appearance:textfield;appearance:textfield}.num-wrap input:focus,.select-wrap select:focus{outline:2px solid var(--brand);outline-offset:1px}.num-suffix{position:absolute;right:12px;color:var(--muted);font-size:13px;pointer-events:none}.num-wrap input{padding-right:56px}.dose-hint{color:var(--muted);font-size:14px;margin:14px 2px}.result-card{background:var(--surface);border:1px solid var(--line);border-radius:var(--r-lg);box-shadow:var(--shadow-card);margin-top:16px;overflow:hidden}.result-main{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1.05fr);gap:28px;padding:26px 26px 22px}.answer-lead{font-size:13px;font-weight:650;text-transform:uppercase;letter-spacing:.06em;color:var(--muted);margin-bottom:10px}.answer-figure{display:flex;align-items:baseline;gap:9px;flex-wrap:wrap}.answer-about{font-size:19px;color:var(--ink-2);font-weight:500}.answer-number{font-size:58px;font-weight:700;letter-spacing:-.03em;line-height:.95;color:var(--ink);font-variant-numeric:tabular-nums}.answer-unit{font-size:21px;color:var(--ink-2);font-weight:550}.answer-range{margin:12px 0 16px;color:var(--ink-2);font-size:14.5px;max-width:42ch;text-wrap:pretty}.evidence-chip{display:inline-flex;align-items:center;gap:7px;font-size:12.5px;font-weight:600;color:var(--ink-2);background:var(--surface-2);border:1px solid var(--line-2);padding:5px 11px 5px 9px;border-radius:999px}.evidence-dot{width:8px;height:8px;border-radius:50%;background:var(--tier-b)}.dose-scale-track{position:relative;height:12px;margin:38px 4px 8px;background:var(--surface-2);border:1px solid var(--line);border-radius:999px}.dose-scale-band{position:absolute;top:-1px;bottom:-1px;background:var(--brand-bg);border:1px solid var(--brand);border-radius:999px;opacity:.9}.dose-scale-point-dot{display:block;width:17px;height:17px;border-radius:50%;background:var(--brand);border:3px solid #fff;box-shadow:0 1px 4px #0f766e80}.dose-scale-point-label{position:absolute;bottom:24px;left:50%;transform:translate(-50%);white-space:nowrap;font-size:20px;font-weight:700;color:var(--brand);font-variant-numeric:tabular-nums}.dose-scale-unit{font-size:13px;font-weight:600;color:var(--ink-2);margin-left:2px}.dose-scale-tick{position:absolute;top:13px;transform:translate(-50%);display:flex;flex-direction:column;align-items:center}.dose-scale-tick-label{font-size:11px;color:var(--muted);margin-top:2px;font-variant-numeric:tabular-nums}.dose-scale-caption{text-align:center;font-size:12.5px;color:var(--muted);margin-top:22px}.bridge{display:flex;align-items:stretch;justify-content:center;gap:6px;width:100%}.bridge-node{flex:1;text-align:center;padding:12px 8px;border-radius:var(--r);background:var(--surface-2);border:1px solid var(--line)}.bridge-node-result{background:var(--brand-bg);border-color:var(--brand)}.bridge-node-val{font-size:23px;font-weight:700;letter-spacing:-.02em;font-variant-numeric:tabular-nums}.bridge-node-result .bridge-node-val{color:var(--brand)}.bridge-unit{font-size:11px;color:var(--muted);margin-left:2px}.bridge-node-name{font-size:13px;font-weight:600;margin-top:2px}.bridge-node-tag{font-size:10.5px;text-transform:uppercase;letter-spacing:.05em;color:var(--muted);margin-top:3px}.bridge-node-prohibited .bridge-node-val{color:var(--danger);text-decoration:line-through}.bridge-node-prohibited{border-color:var(--danger);background:var(--danger-bg)}.bridge-arrow{color:var(--line-2);font-size:18px}.result-restate{display:flex;align-items:baseline;gap:10px;padding:15px 26px;background:var(--surface-2);border-top:1px solid var(--line);font-size:15px;color:var(--ink);font-weight:500}.restate-icon{color:var(--brand);font-size:18px;font-weight:700}.caveat-panel{padding:18px 26px 22px;border-top:1px solid var(--line);background:var(--surface)}.caveat-title{font-size:12.5px;font-weight:650;text-transform:uppercase;letter-spacing:.05em;color:var(--muted);margin-bottom:12px}.caveat-notes{display:flex;flex-direction:column;gap:8px;margin-bottom:12px}.caveat-note{display:flex;flex-direction:column;gap:2px;padding:10px 13px;border-radius:var(--r-sm);border-left:3px solid var(--line-2);background:var(--surface-2)}.caveat-note-head{font-size:12.5px;font-weight:650}.caveat-note-body{font-size:13.5px;color:var(--ink-2);line-height:1.5}.caveat-info{background:var(--surface-2);border-left-color:var(--brand)}.caveat-info .caveat-note-head{color:var(--brand)}.caveat-primary{margin:0 0 8px;font-size:13.5px;color:var(--muted);line-height:1.55;max-width:92ch}.disclosure{margin-top:4px}.disclosure-summary{display:inline-flex;align-items:center;gap:6px;background:none;border:none;cursor:pointer;padding:4px 0;font-size:13px;font-weight:600;color:var(--ink-2)}.disclosure-summary:hover{color:var(--brand)}.disclosure-caret{transition:transform .15s;font-size:10px;color:var(--muted)}.disclosure-body{padding-top:8px}.cite-list{list-style:none;margin:0;padding:0;display:flex;flex-direction:column;gap:12px}.cite-item{padding-left:12px;border-left:2px solid var(--line-2)}.cite-head a{font-size:13.5px;font-weight:600;text-decoration:none}.cite-meta{font-size:12px;color:var(--muted);font-family:var(--mono)}.cite-quote{margin:4px 0 0;font-size:13px;color:var(--ink-2);font-style:italic;line-height:1.5}.refusal-card{display:flex;gap:16px;padding:22px 26px;align-items:flex-start}.refusal-heading{font-size:15px;font-weight:680;color:var(--danger);margin-bottom:4px}.refusal-body{margin:0;font-size:14.5px;color:var(--ink-2);max-width:70ch}.refusal-alt{margin:8px 0 0;font-size:13.5px;color:var(--muted)}.pk-controls{margin-bottom:18px}.pk-note{margin:9px 2px 0;color:var(--ink-2);font-size:14px;max-width:70ch;text-wrap:pretty}.regimen-editor{background:var(--surface);border:1px solid var(--line);border-top:3px solid;border-radius:var(--r);box-shadow:var(--shadow-card);padding:14px 16px 16px}.regimen-editor-head{display:flex;align-items:center;gap:8px;margin-bottom:12px;flex-wrap:wrap}.regimen-dot{width:10px;height:10px;border-radius:50%}.regimen-name{font-size:14.5px;font-weight:650;margin-right:auto}.regimen-action-inner{display:inline-flex;align-items:center;gap:8px;flex-wrap:wrap}.match-btn-sm{padding:5px 11px;font-size:12.5px;display:inline-flex;align-items:center;gap:5px}.match-result-inline{display:inline-flex;align-items:center;gap:7px;font-size:12px}.regimen-fields{display:grid;grid-template-columns:1fr 1fr 1fr;gap:10px}.regimen-fields .num-wrap input{min-width:0;padding-right:12px}.nonlinear-callout{background:linear-gradient(180deg,var(--brand-bg),var(--surface));border:1px solid var(--brand);border-radius:var(--r);padding:16px 18px;margin-bottom:16px}.nonlinear-headline{font-size:18px;font-weight:680;letter-spacing:-.01em;color:var(--ink)}.nonlinear-sub{margin-top:5px;font-size:14px;color:var(--ink-2);max-width:80ch;text-wrap:pretty}.chart-card-title{font-size:14px;font-weight:650;color:var(--ink);margin-bottom:10px}.chart-marker-text{font-size:11px;font-weight:650;font-family:var(--mono)}.match-row{margin-bottom:18px}.match-actions{display:flex;flex-wrap:wrap;align-items:center;gap:8px 10px}.match-btn{border:1px solid var(--line-2);background:var(--surface);color:var(--brand);border-radius:var(--r-sm);padding:8px 14px;font-size:13.5px;font-weight:600;cursor:pointer;transition:background .14s,border-color .14s}.match-btn:hover:not(:disabled){background:var(--brand-bg);border-color:var(--brand)}.match-btn:disabled{opacity:.45;cursor:not-allowed}.match-chip{display:inline-flex;align-items:center;gap:8px;flex-wrap:wrap;background:var(--surface-2);border:1px solid var(--line);border-radius:999px;padding:5px 6px 5px 13px;font-size:13px;color:var(--ink-2);font-weight:500}.match-q{font-weight:650}.match-reset{background:var(--surface);border:1px solid var(--line-2);border-radius:999px;padding:4px 11px;font-size:12px;font-weight:600;color:var(--ink-2);cursor:pointer}.match-help{margin:9px 2px 0;font-size:12.5px;color:var(--muted);max-width:78ch;text-wrap:pretty}.chart-legend{display:flex;gap:18px;margin-bottom:4px;flex-wrap:wrap}.chart-legend-item{display:inline-flex;align-items:center;gap:7px;font-size:13px;font-weight:600;color:var(--ink-2)}.chart-legend-swatch{width:14px;height:3px;border-radius:2px}.chart-axis-label{fill:var(--ink-2);font-size:12px;font-weight:600}.chart-readout{display:flex;flex-wrap:wrap;gap:6px 16px;margin-top:8px;padding:8px 12px;background:var(--surface-2);border-radius:var(--r-sm);font-size:13px}.chart-readout-t{font-family:var(--mono);color:var(--muted)}.chart-readout-v strong{font-variant-numeric:tabular-nums}.metrics-compare{width:100%;border-collapse:collapse;font-size:14px;background:var(--surface);border:1px solid var(--line);border-radius:var(--r);overflow:hidden;box-shadow:var(--shadow-card)}.metrics-compare th,.metrics-compare td{padding:11px 14px;text-align:right;border-bottom:1px solid var(--line);font-variant-numeric:tabular-nums}.metrics-compare thead th{font-size:12.5px;font-weight:650;background:var(--surface-2)}.metric-row-label{color:var(--ink);font-weight:550}.metric-row-unit{color:var(--muted);font-weight:400;font-size:12px}.metric-row-ratio{font-weight:650}.metric-tiles{display:grid;grid-template-columns:repeat(4,1fr);gap:12px}.metric-tile{background:var(--surface);border:1px solid var(--line);border-top:3px solid var(--brand);border-radius:var(--r);padding:13px 15px;box-shadow:var(--shadow-card)}.metric-label{font-size:12px;font-weight:600;color:var(--muted);text-transform:uppercase;letter-spacing:.03em}.metric-value{font-size:24px;font-weight:700;margin-top:4px;letter-spacing:-.02em;font-variant-numeric:tabular-nums}.metric-unit{font-size:13px;color:var(--ink-2);font-weight:550}.pk-footnote{font-size:12.5px;color:var(--muted);margin:14px 2px 0}.sc-form{background:var(--surface);border:1px solid var(--line);border-radius:var(--r-lg);box-shadow:var(--shadow-card);padding:20px 22px;display:flex;flex-direction:column;gap:16px}.sc-field-block{display:flex;flex-direction:column;gap:6px;align-items:stretch}.sc-field-block .select-wrap,.sc-field-block .select-wrap select{width:100%}.sc-field-block .select-wrap select{min-width:0}.sc-text-input{border:1px solid var(--line-2);background:var(--surface);color:var(--ink);border-radius:var(--r-sm);padding:9px 12px;font-size:15px;font-weight:550;font-family:inherit;width:100%}.sc-text-input:focus{outline:2px solid var(--brand);outline-offset:1px}.sc-custom{border-top:1px dashed var(--line-2);padding-top:14px;display:flex;flex-direction:column;gap:14px}.sc-custom-row{display:grid;grid-template-columns:1fr 1fr;gap:14px}.sc-example-note{margin:12px 2px 0;font-size:13px;color:var(--muted);font-style:italic}.sc-card-head{padding:20px 24px 14px;border-bottom:1px solid var(--line)}.sc-card-heading{font-size:13px;font-weight:650;text-transform:uppercase;letter-spacing:.06em;color:var(--muted);margin:0 0 8px}.sc-card-product{margin:0;font-size:15.5px;color:var(--ink)}.sc-card-product-label{color:var(--muted);font-size:13px}.sc-class-default{color:var(--ink-2);font-style:italic}.sc-axes{list-style:none;margin:0;padding:0;display:flex;flex-direction:column}.sc-axis{padding:16px 24px;border-bottom:1px solid var(--line);border-left:4px solid var(--line-2)}.sc-axis-yes{border-left-color:var(--brand)}.sc-axis-head{margin:0;display:flex;align-items:baseline;gap:10px;flex-wrap:wrap}.sc-axis-label{font-size:14px;font-weight:600;color:var(--muted)}.sc-verdict{font-size:19px;font-weight:700;letter-spacing:-.01em;line-height:1.2}.sc-verdict-yes{color:var(--brand)}.sc-verdict-unknown{color:var(--muted)}.sc-axis-reason{margin:7px 0 10px;font-size:13.5px;color:var(--ink-2);line-height:1.5;max-width:52ch;text-wrap:pretty}.sc-axis-evidence{display:flex;align-items:center;gap:12px;flex-wrap:wrap;margin-bottom:6px}.sc-verified{font-size:12px;color:var(--muted)}.sc-note{margin:0;padding:14px 24px;font-size:13.5px;line-height:1.5;color:var(--ink-2);border-top:1px solid var(--line)}.sc-note-head{font-weight:650;color:var(--ink)}.sc-note-mr{background:var(--warn-bg);color:var(--warn);font-weight:550}.sc-custom-prompt{margin:0;padding:18px 20px;font-size:14.5px;color:var(--muted);background:var(--surface-2);border:1px dashed var(--line);border-radius:var(--r)}@media (max-width: 560px){.sc-custom-row{grid-template-columns:1fr}}.disclaimer{margin-top:30px;padding:13px 16px;background:var(--surface-2);border:1px solid var(--line);border-radius:var(--r);display:flex;gap:10px;align-items:flex-start}.disclaimer-text{font-size:12.5px;color:var(--muted-strong);line-height:1.5}.methods-disclosure{margin-top:14px}.methods-link{background:none;border:none;padding:4px 0;min-height:24px;font:inherit;font-size:12.5px;font-weight:600;color:var(--brand);cursor:pointer;text-decoration:underline}.methods-link:hover{color:var(--brand-600)}.all-formulas{margin-top:16px;padding:20px 22px;background:var(--surface);border:1px solid var(--line);border-radius:var(--r);box-shadow:var(--shadow-card)}.all-formulas-title{margin:0 0 6px;font-size:18px;color:var(--ink)}.all-formulas-intro{margin:0 0 18px;font-size:13px;color:var(--muted);line-height:1.5}.all-formulas-list{list-style:none;margin:0;padding:0;display:grid;gap:16px}.formula-card{padding:16px 18px;background:var(--surface-2);border:1px solid var(--line);border-radius:var(--r-sm)}.formula-name{margin:0 0 10px;font-size:15px;color:var(--ink)}.formula-meta{margin:0;display:grid;gap:2px 12px}.formula-meta dt{font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.04em;color:var(--muted);margin-top:8px}.formula-meta dt:first-child{margin-top:0}.formula-meta dd{margin:0;font-size:13px;color:var(--ink-2)}.formula-expression{display:inline-block;font-family:var(--mono);font-size:12.5px;color:var(--ink);background:var(--surface);padding:4px 8px;border:1px solid var(--line);border-radius:var(--r-sm);white-space:pre-wrap}.formula-description{line-height:1.5}.formula-coderef{font-family:var(--mono);font-size:12px;color:var(--muted-strong)}.formula-coderef-detail{margin-top:10px}.formula-coderef-detail>summary{cursor:pointer;font-size:11px;font-weight:600;color:var(--muted-strong);text-transform:uppercase;letter-spacing:.04em}.formula-coderef-detail[open]>summary{margin-bottom:6px}.formula-sources-heading{margin:14px 0 6px;font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.04em;color:var(--muted)}.formula-citation-list{list-style:none;margin:0;padding:0}.formula-citation-item{font-size:12.5px;color:var(--ink-2);line-height:1.5}.formula-citation-item+.formula-citation-item{margin-top:10px;padding-top:10px;border-top:1px solid var(--line)}.formula-citation-link{color:var(--brand);font-weight:600;text-decoration:underline}.formula-citation-identifier{opacity:.85;font-size:.85em}.formula-citation-status{font-size:.8em;font-weight:600}.formula-citation-status--verified{color:var(--tier-a)}.formula-citation-status--textbook{color:var(--tier-b)}.formula-citation-status--pending{color:var(--muted-strong)}.formula-citation-quote-figure{margin:6px 0 0}.formula-citation-quote-frame{font-size:.8em;opacity:.85;margin-bottom:2px}.formula-citation-quote{margin:0;padding-left:10px;border-left:2px solid var(--line-2);font-style:italic;color:var(--ink-2)}.formula-citation-quote-pending{margin:6px 0 0;font-style:italic;color:var(--muted-strong)}.evidence-badge-group{display:inline-flex;align-items:center;gap:10px;flex-wrap:wrap}.show-math-link{background:none;border:none;padding:4px 0;min-height:24px;font:inherit;font-size:12px;font-weight:600;color:var(--brand);cursor:pointer;text-decoration:underline}.show-math-link:hover{color:var(--brand-600)}.show-math-panel{margin-top:12px;padding:14px 16px;background:var(--surface-2);border:1px solid var(--line);border-radius:var(--r-sm)}.show-math-heading{margin:0 0 8px;font-size:13px;color:var(--ink)}.show-math-formula-name{margin:0 0 2px;font-size:13.5px;font-weight:650;color:var(--ink)}.show-math-gloss{margin:0 0 10px;font-size:13px;line-height:1.5;color:var(--ink-2);max-width:60ch;text-wrap:pretty}.show-math-meta{margin:0}.show-math-meta dt{font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.04em;color:var(--muted)}.show-math-meta dd{margin:4px 0 0}.show-math-values{margin-top:12px}.show-math-values-heading{margin:0 0 6px;font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.04em;color:var(--muted)}.show-math-values-list{margin:0}.show-math-value-row{display:flex;justify-content:space-between;gap:12px;font-size:12.5px;color:var(--ink-2);padding:2px 0}.show-math-value-row dt{margin:0}.show-math-value-row dd{margin:0;font-weight:600;color:var(--ink)}@media (max-width: 720px){.app-shell{padding:0 14px 48px}.appbar{padding-left:14px;padding-right:14px}.result-main{grid-template-columns:1fr;gap:22px}.metric-tiles{grid-template-columns:1fr 1fr}.appbar{flex-wrap:wrap}.answer-number{font-size:48px}}@media (max-width: 460px){.bridge{flex-direction:column}.bridge-link{justify-content:center}.bridge-arrow{transform:rotate(90deg)}}:root{--paper: #f3f0e9;--surface: #ffffff;--surface-2: #faf8f3;--ink: #1b1d20;--ink-2: #474c52;--muted: #7a8088;--faint: #a7aab0;--line: #e3ddd0;--line-2: #d2ccbd;--rule: #1b1d20;--cobalt: #1b3c8a;--cobalt-7: #16336f;--cobalt-bg: #eef1f8;--cobalt-tint:#e4e9f4;--clay: #b9531f;--clay-bg: #f8ede4;--tier-a: #1c7d4d;--tier-b: #9a6b08;--tier-c: #a3203a;--warn: #9a6b08;--warn-bg: #faf2dd;--danger: #a3203a;--danger-bg: #fbecef;--r-sm: 3px;--r: 5px;--r-lg: 8px;--shadow: 0 1px 2px rgba(27,29,32,.04), 0 10px 30px -18px rgba(27,29,32,.22);--serif: "Spectral", Georgia, "Times New Roman", serif;--sans: "Golos Text", -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;--mono: "IBM Plex Mono", ui-monospace, SFMono-Regular, Menlo, monospace}*{box-sizing:border-box}html,body{margin:0;padding:0}body{background:var(--paper);color:var(--ink);font-family:var(--sans);font-size:15px;line-height:1.55;-webkit-font-smoothing:antialiased}button,input,select{font-family:inherit}a{color:var(--cobalt)}::selection{background:var(--cobalt-tint)}.masthead{background:var(--cobalt);color:#fff;border-bottom:3px solid var(--cobalt-7)}.masthead-inner{max-width:1060px;margin:0 auto;padding:16px 24px;display:flex;align-items:center;gap:16px}.seal-link{display:inline-flex;flex:none}.seal{width:42px;height:42px;flex:none;border-radius:6px;background:#fff;color:var(--cobalt);display:grid;place-items:center;position:relative;box-shadow:0 0 0 1px #fff6,0 0 0 4px #ffffff1f}.seal svg{width:30px;height:30px}.brand-text{display:flex;flex-direction:column;line-height:1.05;margin-right:auto}.brand-title{font-family:var(--serif);font-size:25px;font-weight:600;letter-spacing:.01em;font-feature-settings:"ss01"}.brand-sub{font-size:11px;letter-spacing:.14em;text-transform:uppercase;color:#ffffffb8;margin-top:4px;font-weight:500}.lang-toggle{display:inline-flex;border:1px solid rgba(255,255,255,.4);border-radius:5px;overflow:hidden;background:transparent}.lang-toggle button{border:none;background:transparent;cursor:pointer;padding:7px 12px;font-size:11.5px;font-weight:700;letter-spacing:.06em;color:#ffffffc7}.lang-toggle button.is-active{background:#fff;color:var(--cobalt)}.subnav{background:var(--surface);border-bottom:1px solid var(--line-2);position:sticky;top:0;z-index:40}.subnav-inner{max-width:1060px;margin:0 auto;padding:0 24px;display:flex;gap:4px}.tab{border:none;background:transparent;cursor:pointer;padding:15px 18px 13px;font-size:14px;font-weight:600;color:var(--muted);border-bottom:3px solid transparent;margin-bottom:-1px;white-space:nowrap;transition:color .14s,border-color .14s}.tab:hover{color:var(--ink)}.tab.is-active{color:var(--cobalt);border-bottom-color:var(--cobalt)}.page{width:100%;max-width:1060px;margin:0 auto;padding:30px 24px 80px}.mode-head{margin-bottom:24px;padding-bottom:18px;border-bottom:1px solid var(--line-2)}.mode-kicker{font-size:11px;font-weight:700;letter-spacing:.14em;text-transform:uppercase;color:var(--clay);margin-bottom:9px}.mode-title{font-family:var(--serif);font-size:32px;font-weight:560;letter-spacing:-.01em;margin:0 0 7px}.mode-intro{margin:0;color:var(--ink-2);font-size:15px;max-width:72ch;text-wrap:pretty}.class-switch{margin-bottom:22px}.seg{display:inline-flex;gap:0;border:1px solid var(--line-2);border-radius:7px;overflow:hidden;background:var(--surface)}.seg-btn{border:none;background:transparent;cursor:pointer;padding:9px 18px;font-size:13.5px;font-weight:600;color:var(--ink-2);white-space:nowrap;border-right:1px solid var(--line-2);transition:background .14s,color .14s}.seg-btn:last-child{border-right:none}.seg-btn:hover{background:var(--surface-2)}.seg-btn.is-active{background:var(--cobalt);color:#fff}.seg-sm .seg-btn{padding:7px 13px;font-size:12.5px}.field{display:inline-flex;flex-direction:column;gap:6px}.field-label{font-size:11px;font-weight:700;letter-spacing:.07em;text-transform:uppercase;color:var(--muted)}.select-wrap,.num-wrap{position:relative;display:inline-flex;align-items:center}.select-wrap select{-moz-appearance:none;appearance:none;-webkit-appearance:none;background:var(--surface);color:var(--ink);border:1px solid var(--line-2);border-radius:var(--r-sm);padding:10px 34px 10px 13px;font-size:14.5px;font-weight:600;cursor:pointer;min-width:158px}.select-caret{position:absolute;right:13px;pointer-events:none;width:0;height:0;border-left:4px solid transparent;border-right:4px solid transparent;border-top:5px solid var(--muted)}.field-accent select{border-color:var(--cobalt);color:var(--cobalt);box-shadow:inset 0 0 0 1px var(--cobalt)}.combo-field{display:inline-flex;flex-direction:column;gap:6px}.combo{position:relative;min-width:188px}.combo-button{display:flex;align-items:center;gap:10px;width:100%;background:var(--surface);color:var(--ink);border:1px solid var(--line-2);border-radius:var(--r-sm);padding:10px 13px;font-size:14.5px;font-weight:600;cursor:pointer;text-align:left;transition:border-color .14s,box-shadow .14s}.combo-button:hover{border-color:var(--ink-2)}.combo.is-open .combo-button{border-color:var(--cobalt);box-shadow:0 0 0 1px var(--cobalt)}.combo-accent .combo-button{border-color:var(--cobalt);color:var(--cobalt);box-shadow:inset 0 0 0 1px var(--cobalt)}.combo-accent.is-open .combo-button{box-shadow:0 0 0 1px var(--cobalt)}.combo-value{flex:1;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.combo-caret{flex:none;width:0;height:0;border-left:4px solid transparent;border-right:4px solid transparent;border-top:5px solid var(--muted)}.combo-pop{position:absolute;top:calc(100% + 6px);left:0;min-width:100%;width:max-content;max-width:320px;z-index:60;background:var(--surface);border:1px solid var(--line-2);border-radius:var(--r);box-shadow:0 18px 44px -16px #1b1d206b;overflow:hidden}.combo-search{display:flex;align-items:center;gap:8px;padding:9px 12px;border-bottom:1px solid var(--line);background:var(--surface-2)}.combo-search-icon{color:var(--muted);font-size:15px;line-height:1}.combo-search-input{border:none;outline:none;background:transparent;font-family:var(--sans);font-size:14px;width:100%;color:var(--ink)}.combo-search-input::placeholder{color:var(--faint)}.combo-list{list-style:none;margin:0;padding:5px;max-height:264px;overflow-y:auto}.combo-option{display:flex;align-items:center;gap:8px;padding:9px 11px;border-radius:var(--r-sm);font-size:14px;cursor:pointer;color:var(--ink-2)}.combo-option-label{flex:1}.combo-option.is-active{background:var(--cobalt-bg);color:var(--ink)}.combo-option.is-selected{color:var(--cobalt);font-weight:700}.combo-check{margin-left:auto;color:var(--cobalt);font-size:12px;flex:none}.combo-empty{padding:16px 12px;font-size:13px;color:var(--muted);text-align:center}.num-wrap input{background:var(--surface);color:var(--ink);border:1px solid var(--line-2);border-radius:var(--r-sm);padding:10px 52px 10px 13px;font-size:15px;font-weight:700;width:100%;min-width:96px;font-variant-numeric:tabular-nums;-moz-appearance:textfield;-webkit-appearance:textfield;appearance:textfield}.num-wrap input::-webkit-outer-spin-button,.num-wrap input::-webkit-inner-spin-button{-webkit-appearance:none;margin:0}.num-wrap input:focus,.select-wrap select:focus{outline:2px solid var(--cobalt);outline-offset:1px}.num-suffix{position:absolute;right:13px;font-size:12px;color:var(--muted);pointer-events:none}.sentence-card{background:var(--surface);border:1px solid var(--line-2);border-radius:var(--r-lg);box-shadow:var(--shadow);padding:24px 26px;border-top:3px solid var(--cobalt)}.equiv-grid{display:grid;grid-template-columns:max-content 1fr;gap:4px 20px;align-items:center}.equiv-rowlabel{font-size:11px;font-weight:700;letter-spacing:.07em;text-transform:uppercase;color:var(--muted);align-self:center;padding:14px 0;white-space:nowrap}.equiv-rowlabel-target{color:var(--cobalt)}.equiv-rowfields{display:flex;align-items:center;gap:12px;flex-wrap:wrap;padding:8px 0}.equiv-rowfields .field,.equiv-rowfields .select-wrap select,.equiv-rowfields .combo{min-width:188px}.equiv-rowfields .num-wrap{width:150px}.equiv-rowfields .num-wrap input{min-width:0}.equiv-join{font-size:13.5px;color:var(--muted);padding:0 2px}.equiv-arrow{grid-column:1;justify-self:center;align-self:center;color:var(--cobalt);font-size:17px;line-height:1}.equiv-arrow-rule{grid-column:2;height:1px;background:var(--line);margin:2px 0}.dose-hint{margin:18px 0 0;padding:30px 28px;text-align:center;border:1px dashed var(--line-2);border-radius:var(--r-lg);background:var(--surface-2);color:var(--muted);font-size:14px;font-style:italic}.result-card{background:var(--surface);border:1px solid var(--line-2);border-radius:var(--r-lg);box-shadow:var(--shadow);margin-top:18px;overflow:hidden}.result-main{display:grid;grid-template-columns:minmax(0,.95fr) minmax(0,1.05fr);gap:32px;padding:26px 28px 24px}.answer-lead{font-size:11px;font-weight:700;letter-spacing:.12em;text-transform:uppercase;color:var(--muted);margin-bottom:12px;padding-bottom:12px;border-bottom:1px solid var(--line)}.answer-figure{display:flex;align-items:baseline;gap:10px;flex-wrap:wrap}.answer-about{font-family:var(--serif);font-size:22px;font-style:italic;color:var(--ink-2);white-space:nowrap}.answer-number{font-family:var(--serif);font-size:66px;font-weight:560;line-height:.9;letter-spacing:-.02em;color:var(--ink);font-variant-numeric:tabular-nums}.answer-unit{font-family:var(--serif);font-size:22px;color:var(--ink-2);white-space:nowrap}.answer-range{margin:16px 0 18px;color:var(--ink-2);font-size:14px;max-width:44ch;text-wrap:pretty}.evidence-chip{display:inline-flex;align-items:center;gap:8px;font-size:11.5px;font-weight:700;letter-spacing:.03em;color:var(--ink-2);background:var(--surface-2);border:1px solid var(--line-2);padding:6px 12px 6px 9px;border-radius:4px;text-transform:uppercase}.evidence-chip strong{color:var(--ink)}.evidence-dot{width:9px;height:9px;border-radius:2px;background:var(--tier-b)}.tier-A .evidence-dot{background:var(--tier-a)}.tier-A strong{color:var(--tier-a)}.tier-B .evidence-dot{background:var(--tier-b)}.tier-B strong{color:var(--tier-b)}.tier-C .evidence-dot{background:var(--tier-c)}.tier-C strong{color:var(--tier-c)}.result-viz{display:flex;align-items:center;justify-content:center}.dose-scale{width:100%}.dose-scale-track{position:relative;height:8px;margin:42px 6px 10px;background:var(--surface-2);border:1px solid var(--line-2);border-radius:999px}.dose-scale-band{position:absolute;top:-1px;bottom:-1px;border-radius:999px;background:var(--cobalt-bg);border:1px solid var(--cobalt)}.dose-scale-point{position:absolute;top:50%;transform:translate(-50%,-50%)}.dose-scale-point-dot{display:block;width:15px;height:15px;border-radius:50%;background:var(--cobalt);border:3px solid var(--surface);box-shadow:0 1px 4px #1b3c8a80}.dose-scale-point-label{position:absolute;bottom:24px;left:50%;transform:translate(-50%);white-space:nowrap;font-family:var(--serif);font-size:22px;font-weight:600;color:var(--cobalt);font-variant-numeric:tabular-nums}.dose-scale-unit{font-size:12px;color:var(--ink-2);margin-left:2px;font-family:var(--sans)}.dose-scale-tick{position:absolute;top:9px;transform:translate(-50%);display:flex;flex-direction:column;align-items:center}.dose-scale-tick-line{width:1px;height:5px;background:var(--line-2)}.dose-scale-tick-label{font-size:10.5px;color:var(--muted);margin-top:3px;font-variant-numeric:tabular-nums}.dose-scale-caption{text-align:center;font-size:12px;color:var(--muted);margin-top:22px}.bridge{display:flex;align-items:stretch;justify-content:center;gap:7px;width:100%}.bridge-node{flex:1;text-align:center;padding:13px 8px;border-radius:var(--r);background:var(--surface-2);border:1px solid var(--line-2)}.bridge-node-anchor{background:transparent;border-style:dashed}.bridge-node-result{background:var(--cobalt-bg);border-color:var(--cobalt)}.bridge-node-val{font-family:var(--serif);font-size:23px;font-weight:600;font-variant-numeric:tabular-nums}.bridge-node-result .bridge-node-val{color:var(--cobalt)}.bridge-unit{font-size:11px;color:var(--muted);margin-left:2px;font-family:var(--sans)}.bridge-node-name{font-size:12.5px;font-weight:700;margin-top:3px}.bridge-node-tag{font-size:10px;text-transform:uppercase;letter-spacing:.06em;color:var(--muted);margin-top:4px}.bridge-link{display:flex;align-items:center}.bridge-arrow{color:var(--line-2);font-size:16px}.result-restate{display:flex;align-items:baseline;gap:11px;padding:16px 28px;background:var(--cobalt-bg);border-top:1px solid var(--line);font-size:14.5px;color:var(--ink);font-family:var(--serif);line-height:1.5}.restate-icon{color:var(--cobalt);font-size:18px;font-weight:700}.caveat-panel{padding:22px 28px 24px;border-top:1px solid var(--line);background:var(--surface-2)}.caveat-title{font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.1em;color:var(--muted);margin-bottom:14px}.caveat-notes{display:flex;flex-direction:column;margin-bottom:6px}.caveat-note{display:flex;flex-direction:column;gap:3px;padding:11px 14px;border-radius:var(--r-sm);border-left:3px solid var(--line-2);background:var(--surface);overflow:hidden;max-height:260px;margin-bottom:9px;transition:max-height .3s ease,opacity .25s ease,margin .3s ease,padding .3s ease,border-width .2s ease}.caveat-note-collapsed{max-height:0;opacity:0;margin-top:0;margin-bottom:0;padding-top:0;padding-bottom:0;border-width:0;pointer-events:none}.caveat-note-head{font-size:12.5px;font-weight:700}.caveat-note-body{font-size:13px;color:var(--ink-2);line-height:1.5}.caveat-warn{background:var(--warn-bg);border-left-color:var(--warn)}.caveat-warn .caveat-note-head{color:var(--warn)}.caveat-danger{background:var(--danger-bg);border-left-color:var(--danger)}.caveat-danger .caveat-note-head{color:var(--danger)}.caveat-info{border-left-color:var(--cobalt)}.caveat-info .caveat-note-head{color:var(--cobalt)}.caveat-primary{margin:0 0 12px;font-size:13px;color:var(--ink-2);line-height:1.6;max-width:94ch}.disclosure{margin-top:6px}.disclosure-summary{display:inline-flex;align-items:center;gap:7px;background:none;border:none;cursor:pointer;padding:5px 0;font-size:12px;font-weight:700;letter-spacing:.05em;text-transform:uppercase;color:var(--cobalt)}.disclosure-caret{display:inline-block;width:0;height:0;border-left:5px solid currentColor;border-top:4px solid transparent;border-bottom:4px solid transparent;transition:transform .15s}.disclosure.is-open .disclosure-caret{transform:rotate(90deg)}.disclosure-body{padding-top:12px}.cite-list{list-style:none;margin:0;padding:0;counter-reset:ref;display:flex;flex-direction:column;gap:14px}.cite-item{position:relative;padding-left:30px}.cite-item:before{counter-increment:ref;content:counter(ref);position:absolute;left:0;top:1px;width:20px;height:20px;display:grid;place-items:center;border-radius:3px;background:var(--cobalt);color:#fff;font-size:11px;font-weight:700;font-variant-numeric:tabular-nums}.cite-head{display:flex;flex-wrap:wrap;align-items:baseline;gap:4px 10px}.cite-head a{font-size:13.5px;font-weight:700;text-decoration:none}.cite-head a:hover{text-decoration:underline}.cite-meta{font-family:var(--mono);font-size:11px;color:var(--muted)}.cite-quote{margin:5px 0 0;font-family:var(--serif);font-size:13.5px;color:var(--ink-2);font-style:italic;line-height:1.55;border-left:2px solid var(--line-2);padding-left:11px}.showmath{margin:0 0 18px;padding:15px 17px;background:var(--cobalt-bg);border:1px solid var(--cobalt-tint);border-radius:var(--r)}.showmath-head{font-size:11px;font-weight:700;letter-spacing:.06em;text-transform:uppercase;color:var(--cobalt-7);margin-bottom:11px}.showmath-expr{font-size:14px;color:var(--cobalt-7);background:var(--surface);border:1px solid var(--cobalt-tint);border-radius:var(--r-sm);padding:11px 13px;overflow-x:auto;white-space:nowrap}.showmath-values{margin:13px 0 0;display:flex;flex-direction:column;gap:0}.showmath-row{display:flex;justify-content:space-between;align-items:baseline;gap:16px;font-size:13px;padding:7px 0;border-bottom:1px dotted var(--cobalt-tint)}.showmath-row:last-child{border-bottom:none}.showmath-label{color:var(--ink-2);margin:0}.showmath-val{color:var(--ink);font-weight:700;font-variant-numeric:tabular-nums;margin:0;text-align:right;white-space:nowrap}.refusal-card{display:flex;gap:17px;padding:24px 28px;align-items:flex-start;border-top:3px solid var(--danger)}.refusal-mark{font-size:30px;color:var(--danger);line-height:1;flex:none}.refusal-heading{font-family:var(--serif);font-size:18px;font-weight:600;color:var(--danger);margin-bottom:5px}.refusal-body{margin:0;font-size:14.5px;color:var(--ink-2);max-width:72ch}.refusal-alt{margin:9px 0 0;font-size:13.5px;color:var(--muted)}.pk-controls{margin-bottom:22px;display:flex;flex-direction:column;gap:10px}.pk-note{margin:0 2px;color:var(--ink-2);font-size:14px;max-width:78ch;text-wrap:pretty}.pk-note-warn{color:var(--danger);font-weight:600}.custom-editor{background:var(--surface);border:1px solid var(--line-2);border-top:3px solid var(--clay);border-radius:var(--r);box-shadow:var(--shadow);padding:18px 20px 20px;margin-bottom:16px}.custom-editor-head{display:flex;align-items:center;gap:9px;margin-bottom:16px}.custom-dot{width:10px;height:10px;border-radius:50%;background:var(--clay)}.custom-editor-title{font-size:12px;font-weight:700;letter-spacing:.06em;text-transform:uppercase}.custom-top{display:flex;flex-wrap:wrap;gap:14px 18px;align-items:flex-end;margin-bottom:16px;padding-bottom:16px;border-bottom:1px solid var(--line)}.custom-name-field{flex:1;min-width:200px}.custom-name-field .num-wrap{width:100%}.custom-name-input{background:var(--surface);color:var(--ink);border:1px solid var(--line-2);border-radius:var(--r-sm);padding:10px 13px;font-family:var(--sans);font-size:14.5px;font-weight:600;width:100%}.custom-name-input:focus{outline:2px solid var(--cobalt);outline-offset:1px}.custom-params{display:grid;grid-template-columns:repeat(auto-fit,minmax(150px,1fr));gap:12px 14px}.custom-params .field,.custom-params .num-wrap{width:100%}.custom-hint{margin:16px 0 0;font-size:12.5px;color:var(--muted);font-style:italic;max-width:84ch;text-wrap:pretty}.regimen-grid{display:grid;grid-template-columns:1fr 1fr;gap:16px;margin-bottom:16px}.regimen-grid-single{grid-template-columns:1fr;max-width:520px}.regimen-editor{background:var(--surface);border:1px solid var(--line-2);border-top:3px solid var(--accent, var(--cobalt));border-radius:var(--r);box-shadow:var(--shadow);padding:16px 18px 18px}.regimen-editor-head{display:flex;align-items:center;gap:9px;margin-bottom:14px;flex-wrap:wrap}.regimen-dot{width:10px;height:10px;border-radius:50%;background:var(--accent, var(--cobalt))}.regimen-name{font-size:12px;font-weight:700;letter-spacing:.06em;text-transform:uppercase;margin-right:auto}.regimen-fields{display:grid;grid-template-columns:1fr 1fr 1fr;gap:11px}.regimen-fields .num-wrap input{min-width:0;padding-right:13px}.regimen-route{display:flex;flex-wrap:wrap;align-items:flex-end;gap:12px 14px;margin-top:14px;padding-top:14px;border-top:1px solid var(--line)}.regimen-route .field{flex:1;min-width:120px}.regimen-route .select-wrap select,.regimen-route .num-wrap input{min-width:0;width:100%}.regimen-route-note{margin:10px 0 0;font-size:12px;color:var(--muted);font-style:italic}.regimen-route-err{margin:10px 0 0;font-size:12.5px;color:var(--danger);font-weight:600}.match-btn{border:1px solid var(--line-2);background:var(--surface);color:var(--cobalt);border-radius:var(--r-sm);padding:8px 14px;font-size:12.5px;font-weight:600;cursor:pointer;display:inline-flex;align-items:center;gap:6px;white-space:nowrap;transition:background .14s,border-color .14s}.match-btn:hover:not(:disabled){background:var(--cobalt-bg);border-color:var(--cobalt)}.match-btn:disabled{opacity:.4;cursor:not-allowed}.match-btn-icon{font-size:13px}.regimen-match{margin-top:16px;padding-top:14px;border-top:1px solid var(--line)}.regimen-action-inner{display:flex;align-items:center;justify-content:space-between;gap:10px 14px;flex-wrap:wrap}.match-result-inline{display:inline-flex;align-items:center;gap:12px;font-size:12.5px}.match-q{display:inline-flex;align-items:center;gap:7px;font-weight:700;white-space:nowrap}.match-q-dot{width:8px;height:8px;border-radius:50%;background:currentColor;flex:none}.match-q-excellent,.match-q-good{color:var(--tier-a)}.match-q-moderate{color:var(--warn)}.match-q-poor{color:var(--danger)}.match-reset{border:1px solid var(--line-2);background:transparent;border-radius:999px;padding:4px 12px;font-size:11px;font-weight:600;color:var(--muted);cursor:pointer;white-space:nowrap}.match-reset:hover{color:var(--ink);border-color:var(--ink-2)}.match-help{margin:0 2px 20px;font-size:12.5px;color:var(--muted);max-width:80ch;text-wrap:pretty}.nonlinear-callout{background:var(--surface);border:1px solid var(--line-2);border-left:4px solid var(--clay);border-radius:var(--r);padding:18px 22px;margin-bottom:18px;box-shadow:var(--shadow)}.nonlinear-headline{font-family:var(--serif);font-size:22px;font-weight:560;letter-spacing:-.01em;color:var(--ink)}.nonlinear-headline strong{color:var(--clay)}.nonlinear-sub{margin-top:8px;font-size:13.5px;color:var(--ink-2);max-width:86ch;text-wrap:pretty}.chart-card{background:var(--surface);border:1px solid var(--line-2);border-radius:var(--r);box-shadow:var(--shadow);padding:18px 20px;margin-bottom:16px}.chart-card-title{font-size:12px;font-weight:700;text-transform:uppercase;letter-spacing:.08em;color:var(--ink);margin-bottom:14px}.chart-caption{font-size:12.5px;color:var(--muted);margin:12px 2px 0;line-height:1.5;max-width:86ch;text-wrap:pretty}.chart{width:100%}.chart-legend{display:flex;gap:20px;margin-bottom:6px;flex-wrap:wrap}.chart-legend-item{display:inline-flex;align-items:center;gap:8px;font-size:12.5px;font-weight:600;color:var(--ink-2)}.chart-legend-swatch{width:16px;height:3px;border-radius:2px}.chart-svg{width:100%;height:auto;display:block}.chart-grid{stroke:var(--line);stroke-width:1}.chart-axis-text{fill:var(--muted);font-size:11px;font-family:var(--mono)}.chart-axis-label{fill:var(--ink-2);font-size:11.5px;font-weight:600}.chart-hairline{stroke:var(--line-2);stroke-width:1;stroke-dasharray:3 3}.chart-readout{display:flex;flex-wrap:wrap;gap:6px 18px;margin-top:10px;padding:9px 13px;background:var(--surface-2);border:1px solid var(--line);border-radius:var(--r-sm);font-size:12.5px;font-variant-numeric:tabular-nums}.chart-readout>span{white-space:nowrap}.chart-readout-t{color:var(--muted);font-family:var(--mono)}.chart-marker-text{font-size:11px;font-weight:700;font-family:var(--mono)}.metrics-compare{width:100%;border-collapse:collapse;font-size:14px;background:var(--surface);border:1px solid var(--line-2);border-radius:var(--r);overflow:hidden;box-shadow:var(--shadow)}.metrics-compare th,.metrics-compare td{padding:12px 15px;text-align:right;border-bottom:1px solid var(--line);font-variant-numeric:tabular-nums}.metrics-compare thead th{font-size:11px;font-weight:700;letter-spacing:.06em;text-transform:uppercase;background:var(--surface-2);color:var(--ink-2)}.metrics-compare th:first-child,.metrics-compare td:first-child{text-align:left}.metrics-compare tbody tr:last-child td{border-bottom:none}.metric-row-label{color:var(--ink);font-weight:600}.metric-row-unit{color:var(--muted);font-weight:400;font-size:11.5px}.metric-row-ratio{font-weight:700}.metric-tiles{display:grid;grid-template-columns:repeat(4,1fr);gap:13px}.metric-tile{background:var(--surface);border:1px solid var(--line-2);border-top:3px solid var(--accent, var(--cobalt));border-radius:var(--r);padding:14px 16px;box-shadow:var(--shadow)}.metric-label{font-size:11px;font-weight:700;color:var(--muted);text-transform:uppercase;letter-spacing:.06em}.metric-value{font-family:var(--serif);font-size:28px;font-weight:560;margin-top:5px;letter-spacing:-.01em;font-variant-numeric:tabular-nums}.metric-unit{font-size:12.5px;color:var(--ink-2);font-family:var(--sans);margin-left:3px}.pk-footnote{font-size:12px;color:var(--muted);margin:16px 2px 0;font-style:italic}.sc-form{background:var(--surface);border:1px solid var(--line-2);border-top:3px solid var(--cobalt);border-radius:var(--r-lg);box-shadow:var(--shadow);padding:22px 24px;margin-bottom:16px}.sc-form .combo-field{width:100%;max-width:460px}.sc-form .combo{min-width:0;width:100%}.field-hint{margin:10px 2px 0;font-size:12.5px;color:var(--muted)}.sc-custom{margin-top:18px;padding-top:18px;border-top:1px solid var(--line)}.sc-field-block{display:flex;flex-direction:column;gap:6px;margin-top:14px}.sc-text-input{background:var(--surface);color:var(--ink);border:1px solid var(--line-2);border-radius:var(--r-sm);padding:10px 13px;font-family:var(--sans);font-size:14.5px;font-weight:600;width:100%;max-width:360px}.sc-text-input:focus{outline:2px solid var(--cobalt);outline-offset:1px}.sc-custom-row{display:flex;flex-wrap:wrap;gap:14px 18px;margin-top:14px}.sc-custom-row .combo-field,.sc-custom-row .field{flex:1;min-width:200px}.sc-custom-row .combo{min-width:0;width:100%}.sc-example-note{margin:0 2px 16px;font-size:12.5px;color:var(--muted);font-style:italic}.sc-custom-prompt{margin:0 2px;padding:18px 20px;background:var(--surface-2);border:1px dashed var(--line-2);border-radius:var(--r);font-size:14px;color:var(--ink-2)}.sc-card{padding:0}.sc-card-head{padding:22px 26px 16px;border-bottom:1px solid var(--line)}.sc-card-heading{font-family:var(--serif);font-size:22px;font-weight:560;margin:0 0 8px}.sc-card-product{margin:0;font-size:14px;color:var(--ink-2)}.sc-card-product-label{font-weight:700;text-transform:uppercase;font-size:11px;letter-spacing:.06em;color:var(--muted)}.sc-class-default{color:var(--muted)}.sc-axes{list-style:none;margin:0;padding:0}.sc-axis{padding:18px 26px;border-bottom:1px solid var(--line);border-left:4px solid var(--line-2)}.sc-axis:last-child{border-bottom:none}.sc-axis-yes{border-left-color:var(--tier-a)}.sc-axis-caution{border-left-color:var(--warn)}.sc-axis-no{border-left-color:var(--danger)}.sc-axis-unknown{border-left-color:var(--muted)}.sc-axis-head{display:flex;align-items:baseline;justify-content:space-between;gap:14px;flex-wrap:wrap}.sc-axis-label{font-size:12px;font-weight:700;letter-spacing:.04em;text-transform:uppercase;color:var(--ink-2)}.sc-verdict{display:inline-flex;align-items:center;gap:7px;font-family:var(--serif);font-size:22px;font-weight:600;line-height:1}.sc-verdict-sym{display:inline-grid;place-items:center;width:22px;height:22px;border-radius:50%;font-family:var(--sans);font-size:12px;font-weight:700;color:#fff}.sc-verdict-yes{color:var(--tier-a)}.sc-verdict-yes .sc-verdict-sym{background:var(--tier-a)}.sc-verdict-caution{color:var(--warn)}.sc-verdict-caution .sc-verdict-sym{background:var(--warn)}.sc-verdict-no{color:var(--danger)}.sc-verdict-no .sc-verdict-sym{background:var(--danger)}.sc-verdict-unknown{color:var(--muted);font-size:18px}.sc-verdict-unknown .sc-verdict-sym{background:var(--muted)}.sc-axis-reason{margin:10px 0 0;font-size:13.5px;color:var(--ink-2);line-height:1.55;max-width:88ch;text-wrap:pretty}.sc-axis-evidence{display:flex;align-items:center;gap:12px;margin-top:12px;flex-wrap:wrap}.sc-verified{font-size:11.5px;color:var(--muted);font-variant-numeric:tabular-nums;white-space:nowrap}.sc-axis .disclosure{margin-top:10px}.cite-nolink{font-size:13.5px;font-weight:700;color:var(--ink)}.sc-note{margin:0;padding:14px 26px;font-size:13px;line-height:1.55}.sc-note-mr{background:var(--warn-bg);color:var(--ink-2);border-top:1px solid var(--line)}.sc-note-pk{background:var(--surface-2);color:var(--ink-2);border-top:1px solid var(--line)}.sc-note-head{font-weight:700;color:var(--ink)}.fractional-panel{border-top:3px solid var(--clay)}.fractional-input{display:inline-flex;flex-direction:column;gap:6px;margin-bottom:4px}.fractional-input .num-wrap{width:200px}.fractional-result{margin-top:16px}.fractional-table thead th,.fractional-table td:first-child{white-space:nowrap}.fractional-oor{text-align:center;color:var(--muted);font-style:italic;font-family:var(--sans)}.fractional-delta{margin:16px 2px 0;font-size:14px;line-height:1.6;color:var(--ink);background:var(--cobalt-bg);border-left:3px solid var(--cobalt);padding:13px 16px;border-radius:var(--r-sm);text-wrap:pretty}.fractional-evidence{display:flex;align-items:center;gap:14px;flex-wrap:wrap;margin-top:14px}.fractional-safety{font-size:12.5px;color:var(--muted);font-style:italic;max-width:70ch;text-wrap:pretty}.fractional-out-of-band{margin-top:14px;padding:16px 18px;background:var(--surface-2);border:1px solid var(--line-2);border-radius:var(--r)}.fractional-oob-head{font-weight:700;font-size:14px;margin-bottom:5px}.fractional-oob-body{margin:0;font-size:13px;color:var(--ink-2)}.methods-disclosure{max-width:1060px;margin:14px auto 0;padding:0 24px}.methods-link{display:inline-flex;align-items:center;gap:9px;background:var(--surface);border:1px solid var(--line-2);border-radius:999px;cursor:pointer;padding:9px 18px;font-family:var(--sans);font-size:12.5px;font-weight:700;letter-spacing:.04em;text-transform:uppercase;color:var(--cobalt);white-space:nowrap;transition:border-color .14s,background .14s}.methods-link:hover{border-color:var(--cobalt);background:var(--cobalt-bg)}.methods-caret{display:inline-block;width:0;height:0;border-left:6px solid currentColor;border-top:5px solid transparent;border-bottom:5px solid transparent;transition:transform .15s}.methods-link[aria-expanded=true] .methods-caret{transform:rotate(90deg)}.methods-catalog{margin-top:16px;background:var(--surface);border:1px solid var(--line-2);border-top:3px solid var(--cobalt);border-radius:var(--r-lg);box-shadow:var(--shadow);padding:26px 28px}.methods-title{font-family:var(--serif);font-size:24px;font-weight:560;margin:0 0 8px}.methods-intro{margin:0 0 22px;font-size:14px;color:var(--ink-2);max-width:80ch;text-wrap:pretty}.formula-list{display:flex;flex-direction:column;gap:0}.formula-entry{padding:20px 0;border-top:1px solid var(--line)}.formula-entry:first-child{padding-top:0;border-top:none}.formula-title{font-size:15px;font-weight:700;margin:0 0 12px}.formula-expr{background:var(--surface-2);border:1px solid var(--line);border-radius:var(--r-sm);padding:12px 15px;font-size:14px;color:var(--cobalt-7);overflow-x:auto;white-space:nowrap}.formula-desc{margin:12px 0 14px;font-size:13.5px;color:var(--ink-2);line-height:1.55;max-width:88ch;text-wrap:pretty}.formula-sources-label{display:block;font-size:11px;font-weight:700;letter-spacing:.06em;text-transform:uppercase;color:var(--muted);margin-bottom:10px}.disclaimer{margin-top:32px;padding:14px 17px;background:var(--surface);border:1px solid var(--line-2);border-left:4px solid var(--warn);border-radius:var(--r);display:flex;gap:11px;align-items:flex-start}.disclaimer-icon{color:var(--warn);font-size:15px;line-height:1.4;flex:none}.disclaimer-text{font-size:12.5px;color:var(--ink-2);line-height:1.5}@media (max-width: 760px){.result-main{grid-template-columns:1fr;gap:26px}.regimen-grid{grid-template-columns:1fr}.metric-tiles{grid-template-columns:1fr 1fr}.subnav-inner{overflow-x:auto}.mode-title{font-size:26px}.answer-number{font-size:54px}}@media (max-width: 460px){.equiv-grid{grid-template-columns:1fr;gap:2px 0}.equiv-arrow{grid-column:1;justify-self:start}.equiv-arrow-rule{grid-column:1}.equiv-rowfields .field,.equiv-rowfields .select-wrap select,.equiv-rowfields .combo,.equiv-rowfields .combo-field{min-width:0;width:100%}.equiv-rowfields{width:100%}.bridge{flex-direction:column}.bridge-link{justify-content:center}.bridge-arrow{transform:rotate(90deg)}}html{scroll-padding-top:5rem}.skip-link{position:absolute;left:.5rem;top:-3rem;z-index:100;padding:.5rem .85rem;background:var(--surface);color:var(--cobalt);border:2px solid var(--cobalt);border-radius:var(--r);font-size:.9375rem;font-weight:600;text-decoration:none;transition:top .15s ease}.skip-link:focus{top:.5rem}.sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}:focus-visible{outline:2px solid var(--cobalt);outline-offset:2px;border-radius:4px}#main:focus,#main:focus-visible{outline:none}.mode-wrap{display:block}@media (prefers-reduced-motion: reduce){*{animation-duration:.001ms!important;animation-iteration-count:1!important;transition-duration:.001ms!important}.skip-link,.caveat-note{transition:none}.citation-disclosure::details-content{transition:none}}